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The X-linked intellectual disability gene product and E3 ubiquitin ligase KLHL15 degrades doublecortin proteins to constrain neuronal dendritogenesis

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.10.02.324285Source: DataRank Database

The X-linked intellectual disability gene product and E3 ubiquitin ligase KLHL15 degrades doublecortin proteins to constrain neuronal dendritogenesis is a research paper published in bioRxiv (Cold Spring Harbor Laboratory) (2020). On theSindex it has a DataRank of 0.

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Enrichment:Funding (3 grants)OA: greenTopics (35)IDs (PubMed, OpenAlex)

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Authors (4)

Ronald A. Merrill ORCID,Andrew Y. Usachev ORCID,Stefan Strack ORCID,Jianing Song ORCID

Live enrichment

PubMed:23304386 OpenAlex:https://openalex.org/W3089654565

National Institutes of Health

Grant: 1R21MH113352-01

PP2A in Neurodevelopmental Disorders

National Institutes of Health

Grant: 5R21MH115673-02

Mitochondrial AKAP1 signaling in chronic stress-induced prefrontal structural & functional plasticity

National Institutes of Health

Grant: 5R01DK116624-04

Targeting Mitochondrial Fission for Neuroprotection in Diabetic Neuropathy

greenLicense: https://www.biorxiv.org/about/FAQ#license

repositoryhttps://www.biorxiv.org/content/biorxiv/early/2020/10/02/2020.10.02.324285.full.pdf

publisherhttps://syndication.highwire.org/content/doi/10.1101/2020.10.02.324285

repositoryhttps://doi.org/10.1101/2020.10.02.324285

https://doi.org/10.1074/jbc.ra120.016210

Fields of Study

Ubiquitin and proteasome pathwaysGenetics and Neurodevelopmental DisordersMicrotubule and mitosis dynamics0301 basic medicine0303 health sciences03 medical and health sciences

Keywords

DoublecortinUbiquitin ligaseBiologyUbiquitinSignal transducing adaptor proteinProteostasisCell biologyGeneticsGeneNeuroscienceHippocampal formationDentate gyrusDoublecortin Domain ProteinsNeuronsDoublecortin ProteinUbiquitin-Protein LigasesBlotting, WesternMicrofilament ProteinsNeuropeptidesUbiquitinationHEK293 CellsIntellectual DisabilityCOS CellsChlorocebus aethiopsAnimalsHumansImmunoprecipitationMicrotubule-Associated ProteinsResearch Article