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Hypertrophic cardiomyopathy ß-cardiac myosin mutation (P710R) leads to hypercontractility by disrupting super-relaxed state

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.11.10.375493Source: DataRank Database

Hypertrophic cardiomyopathy ß-cardiac myosin mutation (P710R) leads to hypercontractility by disrupting super-relaxed state is a research paper published in bioRxiv (Cold Spring Harbor Laboratory) (2020). On theSindex it has a DataRank of 0. It has been cited 4 times.

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (11 grants)OA: greenTopics (56)IDs (PubMed, OpenAlex)SDGs (2)

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Authors (17)

Chao Liu ORCID,Makenna M. Morck ORCID,Kristina B. Kooiker ORCID,Gwanghyun Jung ORCID,Dan Song ORCID

Live enrichment

PubMed:19162232 OpenAlex:https://openalex.org/W3113603657

National Institutes of Health

Grant: 3U01HL133359-05S1

Multiscale modeling of inherited cardiomyopathies and therapeutic interventions

National Institutes of Health

Grant: 3R01HL117138-05S1

Molecular characterization of cardiomyopathy mutations in human cardiac myosin

National Institutes of Health

Grant: 1S10RR026775-01

Shared TIRF and Patterned Illumination Fluorescence Microscope

National Institutes of Health

Grant: 5RM1GM131981-03

From proteins to cells to tissues: A multi-scale assessment of biomechanical regulation by the myosin molecular motor

Swiss National Science Foundation

Grant: 164954

Enabling with microfluidics the use of human-induced pluripotent stem-cell cardiomyocyte (hiPSC-CM) as a model for high-throughput cardiotoxicity and cardiomyopathy studies at the single cell level

National Institutes of Health

Grant: 5R01GM033289-23

Myosin Movement in Vitro - Molecular Characterization

National Institutes of Health

Grant: 5R01HL149164-03

Length-dependent activation in human myocardium

National Institutes of Health

Grant: 4R33HL123655-03

hiPSC-Cardiomyocytes to Screen Variants Predictive of Doxorubicin Cardiotoxicity

Swiss National Science Foundation

Grant: 180825

Manipulating the microenvironment to study outside-in mechanosignaling in cardiomyopathy onset and progression using cardiomyocytes derived from human stem cells

National Institutes of Health

Grant: 5T32GM007276-36

Cellular and Molecular Biology Training Program

National Institutes of Health

Grant: 5T32HL094274-13

Training in Myocardial Biology at Stanford

greenLicense: https://www.biorxiv.org/about/FAQ#license

repositoryhttps://www.biorxiv.org/content/biorxiv/early/2020/12/18/2020.11.10.375493.full.pdf

publisherhttps://syndication.highwire.org/content/doi/10.1101/2020.11.10.375493

repositoryhttps://doi.org/10.1101/2020.11.10.375493

https://doi.org/10.1073/pnas.2025030118

Fields of Study

Cardiomyopathy and Myosin StudiesMuscle Physiology and DisordersCardiovascular Effects of Exercise0301 basic medicine03 medical and health sciences0303 health sciences

Keywords

MYH7MyosinHypertrophic cardiomyopathyActinMutationBiologyCell biologyMyosin light-chain kinaseGeneticsBiochemistryCardiomyopathy1.1 Normal biological development and functioningInduced Pluripotent Stem Cells610BioengineeringCardiovascularModels, BiologicalCell LineVentricular MyosinsMiceMyofibrilsUnderpinning researchModelsbeta-cardiac myosin2.1 Biological and endogenous factorsAnimalsHumansGenetic Predisposition to DiseaseMyocytes, CardiacAetiologyCell SizeMyocytesStem Cell Research - Induced Pluripotent Stem CellStem Cell Research - Induced Pluripotent Stem Cell - HumanhiPSC-CMs600Biological SciencesCardiomyopathy, HypertrophicStem Cell ResearchBiologicalMyocardial Contractionβ-cardiac myosinActinsBiomechanical PhenomenaHeart Diseasesuper relaxed stateHypertrophicoptical trappingCalciumCardiac

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being