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Disease related mutations in PI3Kγ disrupt regulatory C-terminal dynamics and reveals a path to selective inhibitors

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.12.01.406264Source: DataRank Database

Disease related mutations in PI3Kγ disrupt regulatory C-terminal dynamics and reveals a path to selective inhibitors is a research paper published in bioRxiv (Cold Spring Harbor Laboratory) (2020). On theSindex it has a DataRank of 0.

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (4 grants)OA: greenTopics (40)IDs (PubMed, OpenAlex)SDGs (2)

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Authors (9)

Zied Gaieb ORCID,Kaelin D. Fleming ORCID,Chiara Borsari ORCID,Noah J Harris ORCID,Brandon E. Moeller ORCID

Live enrichment

PubMed:19910364 OpenAlex:https://openalex.org/W3110041392

Canadian Institutes of Health Research

Grant: unidentified

unidentified

National Institutes of Health

Grant: 5P01CA234228-03

APOBEC MUTAGENESIS IN BREAST CANCER

National Institutes of Health

Grant: 5R01GM132826-03

A MULTISCALE APPROACH TO TARGET THE ACHILLES HEEL OF P53 CANCER MUTANTS

Swiss National Science Foundation

Grant: 189065

Distinct PI3Kg Complexes in Inflammation, Allergy and Metabolic Control

greenLicense: cc-by

repositoryhttps://www.biorxiv.org/content/biorxiv/early/2020/12/02/2020.12.01.406264.full.pdf

publisherhttps://syndication.highwire.org/content/doi/10.1101/2020.12.01.406264

repositoryhttps://doi.org/10.1101/2020.12.01.406264

https://doi.org/10.7554/elife.64691

Fields of Study

Chronic Lymphocytic Leukemia ResearchPI3K/AKT/mTOR signaling in cancerImmunodeficiency and Autoimmune Disorders0301 basic medicine0303 health sciences03 medical and health sciences

Keywords

Allosteric regulationPI3K/AKT/mTOR pathwayKinaseMutantP110αProtein subunitCell biologyPhosphoinositide 3-kinaseSmall moleculeComputational biologyBiologyChemistryEnzymeSignal transductionBiochemistryGeneQH301-705.5ScienceQRImmunologic Deficiency SyndromesHDX-MS; PI3K; PIK3CG; biochemistry; chemical biology; human; hydrogen exchange; kinases; molecular biophysics; molecular dynamics; structural biologyhydrogen exchangePIK3CGPI3Kmolecular dynamicskinasesBiochemistry and Chemical BiologyMutationMedicineClass Ib Phosphatidylinositol 3-KinaseHumansHDX-MSBiology (General)

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being