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Excision of mutagenic replication-blocking lesions suppresses cancer but promotes cytotoxicity and lethality in nitrosamine-exposed mice

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.01.12.426356Source: DataRank Database

Excision of mutagenic replication-blocking lesions suppresses cancer but promotes cytotoxicity and lethality in nitrosamine-exposed mice is a research paper published in bioRxiv (Cold Spring Harbor Laboratory) (2021). On theSindex it has a DataRank of 0.

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (5 grants)OA: greenTopics (42)IDs (PubMed, OpenAlex)SDGs (1)

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Authors (15)

Joshua J. Corrigan,Amanda L. Armijo ORCID,Ilana S. Nazari ORCID,Ishwar N. Kohale ORCID,Dorothea K. Torous

Live enrichment

PubMed:21097893 OpenAlex:https://openalex.org/W3119495504

National Institutes of Health

Grant: 5T32ES007020-24

TRAINING GRANT IN ENVIRONMENTAL TOXICOLOGY

National Institutes of Health

Grant: 3P42ES027707-03S1

Science and Engineering for Sensors, Mechanisms, and Biomarkers of Exposures

National Institutes of Health

Grant: 5R01CA080024-04

CHROMOSOMAL PROBES FOR MUTAGENESIS BY CARCINOGENS

National Institutes of Health

Grant: 5P41EB015871-28

MIT Laser Biomedical Research Center (P41-RR02594)

National Institutes of Health

Grant: 2P30ES002109-11

TOXICOLOGY CORE UNIT

greenLicense: cc-by

repositoryhttps://www.biorxiv.org/content/biorxiv/early/2021/01/13/2021.01.12.426356.full.pdf

publisherhttps://syndication.highwire.org/content/doi/10.1101/2021.01.12.426356

repositoryhttps://doi.org/10.1101/2021.01.12.426356

repositoryhttps://hdl.handle.net/1721.1/133516.2

Fields of Study

Epigenetics and DNA MethylationDNA Repair MechanismsCarcinogens and Genotoxicity Assessment0301 basic medicine03 medical and health sciences

Keywords

NitrosamineDNA damageBase excision repairDNA repairDNA glycosylaseCytotoxicityCancerCarcinogenSynthetic lethalityCancer researchDNAChemistryLethalityBiologyMolecular biologyCell biologyGeneticsBiochemistryIn vitroDNA ReplicationNitrosaminesCell DeathLiver NeoplasmsMice, TransgenicDNA GlycosylasesHistonesMice, Inbred C57BLLiverMutagenesisChromosomal InstabilityNeoplasmsBiomarkers, TumorAnimalsDiethylnitrosamineDisease SusceptibilityHomologous RecombinationMicronuclei, Chromosome-Defective

Sustainable Development Goals

SDG 3: 3. Good health