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GRP78 binds SARS-CoV-2 Spike protein and ACE2 and GRP78 depleting antibody blocks viral entry and infection in vitro

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.01.20.427368Source: DataRank Database

GRP78 binds SARS-CoV-2 Spike protein and ACE2 and GRP78 depleting antibody blocks viral entry and infection in vitro is a research paper published in bioRxiv (Cold Spring Harbor Laboratory) (2021). On theSindex it has a DataRank of 0. It has been cited 12 times.

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Open Access12 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (5 grants)OA: greenTopics (25)IDs (PubMed, OpenAlex)SDGs (2)

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Findable (1/2)

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Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (7)

Dat P. Ha ORCID,Da‐Wei Yeh ORCID,Richard Van Krieken ORCID,Parkash S. Gill ORCID,Keigo Machida ORCID

Live enrichment

PubMed:21097893 OpenAlex:https://openalex.org/W3123223415

National Institutes of Health

Grant: 1R01AA025204-01A1

NANOG-positive cancer stem cells in liver oncogenesis induced by alcohol and HCV

National Institutes of Health

Grant: 3R01CA027607-33S1

Stress Induction of Glucose Regulated Protein GRP78/BiP

National Institutes of Health

Grant: 5R21AA025470-02

LncRNA with MSI2 and super-enhancer in liver cancer stem cells induced by alcohol

National Institutes of Health

Grant: 3P50AA011999-12S1

Southern California Research Center for ALPD and Cirrhosis

National Institutes of Health

Grant: 5R01CA238029-02

Targeting Cancer through Suppressing Stress Induction of GRP78/BiP

greenLicense: cc-by-nc-nd

repositoryhttps://www.biorxiv.org/content/biorxiv/early/2021/01/20/2021.01.20.427368.full.pdf

publisherhttps://syndication.highwire.org/content/doi/10.1101/2021.01.20.427368

repositoryhttps://doi.org/10.1101/2021.01.20.427368

Europe_PMChttps://europepmc.org/article/PPR/PPR351155

Fields of Study

Endoplasmic Reticulum Stress and DiseaseHeat shock proteins researchSARS-CoV-2 and COVID-19 Research0301 basic medicine0303 health sciences03 medical and health sciences

Keywords

Viral entryVirologyCoronavirusBiologyMonoclonal antibodyAntibodyIn vitroVero cellEndocytosisHEK 293 cellsCell cultureCell biologyReceptorVirusImmunologyCoronavirus disease 2019 (COVID-19)MedicineViral replicationGenetics

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being