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Comprehensive phenotypic analysis of the Dp1Tyb mouse strain reveals a broad range of Down Syndrome-related phenotypes

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.02.11.430828Source: DataRank Database

Comprehensive phenotypic analysis of the Dp1Tyb mouse strain reveals a broad range of Down Syndrome-related phenotypes is a research paper published in bioRxiv (Cold Spring Harbor Laboratory) (2021). On theSindex it has a DataRank of 0. It has been cited 1 time.

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Enrichment:Funding (6 grants)OA: greenTopics (55)IDs (PubMed, OpenAlex)SDGs (1)

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Authors (26)

Heather Cater ORCID,Sheona Watson-Scales,Simon Greenaway,Jennifer Müller ORCID,Dorota Gibbins

Live enrichment

PubMed:26207759 OpenAlex:https://openalex.org/W3127161633

Wellcome Trust

Grant: 080174

A genetic dissection of brain and heart phenotypes in the Tc1 transchromosomic mouse model of Down syndrome

UK Research and Innovation

Grant: MC_U142684171

Bioinformatics for mouse genomics and genetics

Wellcome Trust

Grant: 098327

Understanding Down syndrome phenotypes through innovative mouse genetics.

National Institutes of Health

Grant: 5UM1HG006370-10

Mouse Phenotyping Informatics Infrastructure - MP12

Wellcome Trust

Grant: 098328

Understanding Down syndrome phenotypes through innovative mouse genetics.

European Commission

Grant: 312325

Development of mouse mutant resources for functional analyses of human diseases - Enhancing the translation of research into innovation

greenLicense: cc-by

repositoryhttps://www.biorxiv.org/content/biorxiv/early/2021/02/11/2021.02.11.430828.full.pdf

publisherhttps://syndication.highwire.org/content/doi/10.1101/2021.02.11.430828

repositoryhttps://doi.org/10.1101/2021.02.11.430828

repositoryhttps://discovery.ucl.ac.uk/id/eprint/10135671/

Fields of Study

Down syndrome and intellectual disability researchGenetics and Neurodevelopmental DisordersGenomics and Rare Diseases0301 basic medicine0303 health sciences03 medical and health sciences

Keywords

PhenotypeBiologyDown syndromeTrisomyGeneticsGeneCraniofacialChromosome 21ChromosomeHippocampusmemoryHearingPathologyRB1-214ErythropoiesisChemical Biology & High ThroughputHuman Biology & PhysiologydiabetesRespirationGenome Integrity & RepairRAnemiacraniofacial developmentHeart Function TestsMedicineGenetics & GenomicsLocomotionResearch ArticleModel organismsmouse modelImmunologyPrediabetic StateSignalling & OncogenesGenes, DuplicateEvoked Potentials, Auditory, Brain StemAnimalssleepComputational & Systems BiologyAmyloid beta-PeptidesBone DevelopmentFOS: Clinical medicineCell BiologyhaematopoiesisTumour BiologyMice, Inbred C57BLDisease Models, AnimalOtitis MediaGene Expression RegulationDevelopmental Biology

Sustainable Development Goals

SDG 0: Good health and well-being