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Targeting Gys1 with AAV‐SaCas9 decreases pathogenic polyglucosan bodies and neuroinflammation in Adult Polyglucosan Body and Lafora disease mouse models

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.02.12.430952Source: DataRank Database

Targeting Gys1 with AAV‐SaCas9 decreases pathogenic polyglucosan bodies and neuroinflammation in Adult Polyglucosan Body and Lafora disease mouse models is a research paper published in bioRxiv (Cold Spring Harbor Laboratory) (2021). On theSindex it has a DataRank of 0. It has been cited 2 times.

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Open Access2 citations

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Enrichment:Funding (1 grants)OA: greenTopics (18)IDs (PubMed)SDGs (2)

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Accessible (1/2)

Open Access

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Reusable (0/3)

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Authors (10)

Dikran R. Guisso ORCID,Sahba Kasiri ORCID,Jun Wu ORCID,Matthew Dear,Brandy Verhalen

Live enrichment

PubMed:21097893

National Institutes of Health

Grant: 5P01NS097197-04

Lafora Epilepsy - Basic mechanisms to therapy

greenLicense: cc-by-nc-nd

repositoryhttps://www.biorxiv.org/content/biorxiv/early/2021/02/12/2021.02.12.430952.full.pdf

publisherhttps://syndication.highwire.org/content/doi/10.1101/2021.02.12.430952

https://doi.org/10.1007/s13311-021-01040-7

https://doi.org/10.1101/2021.02.12.430952

https://pubmed.ncbi.nlm.nih.gov/33830476

Fields of Study

0301 basic medicine0303 health sciences03 medical and health sciences

Keywords

Gene EditingBrainGlycogen Storage DiseaseProof of Concept StudyDisease Models, AnimalMiceGlycogen SynthaseLafora DiseaseNeuroinflammatory DiseasesAnimalsRNA, MessengerCRISPR-Cas SystemsNervous System DiseasesGlucansGlycogen

Sustainable Development Goals

SDG 2: 2. Zero hungerSDG 3: 3. Good health