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Massively parallel characterization of CYP2C9 variant enzyme activity and abundance

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.03.12.435209Source: DataRank Database

Massively parallel characterization of CYP2C9 variant enzyme activity and abundance is a research paper published in bioRxiv (Cold Spring Harbor Laboratory) (2021). On theSindex it has a DataRank of 0. It has been cited 11 times.

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Open Access11 citations

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (5 grants)OA: greenTopics (38)IDs (PubMed, OpenAlex)SDGs (2)

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Authors (10)

Melissa A. Chiasson ORCID,Matthew G. McDonald ORCID,Lai Hong Wong ORCID,Katherine A. Sitko ORCID,Gabriel Boyle ORCID

Live enrichment

PubMed:21097893 OpenAlex:https://openalex.org/W3137479900

National Institutes of Health

Grant: 5R24GM115277-03

F-CAP: Functionalization of Variants in Clinically Actionable Pharmacogenes

National Institutes of Health

Grant: 5T32HG000035-04

INTERDISCIPLINARY TRAINING IN GENOMIC SCIENCE

National Institutes of Health

Grant: 1F32GM011669-01

MOLECULAR GENETICS OF TEKTIN PROTEINS

National Institutes of Health

Grant: 1Z01HG000035-01

SYNTENIC CHROMOSOMAL REGIONS OF HUMAN DOMESTIC DOG AND CAT

National Institutes of Health

Grant: 5R01GM132162-03

Comprehensive, context-aware, functional analysis of Cytochrome P450 variants

greenLicense: cc-by-nc

repositoryhttps://www.biorxiv.org/content/biorxiv/early/2021/03/14/2021.03.12.435209.full.pdf

publisherhttps://syndication.highwire.org/content/doi/10.1101/2021.03.12.435209

repositoryhttps://doi.org/10.1101/2021.03.12.435209

https://doi.org/10.1016/j.ajhg.2021.07.001

Fields of Study

Pharmacogenetics and Drug MetabolismComputational Drug Discovery MethodsStatistical Methods in Clinical Trials0301 basic medicine0303 health sciences03 medical and health sciences

Keywords

Missense mutationCYP2C9Cytochrome P450Massive parallel sequencingBiologyEnzymeGeneticsComputational biologyMutationGeneBiochemistryDNA sequencingModels, MolecularProtein Conformation, alpha-HelicalBinding SitesPolymorphism, GeneticPrescription DrugsMutation, MissenseSaccharomyces cerevisiaeHigh-Throughput Screening AssaysXenobioticsPhenytoinMutagenesis, Site-DirectedHumansProtein Conformation, beta-StrandProtein Interaction Domains and MotifsTransgenesWarfarinCytochrome P-450 CYP2C9Enzyme AssaysGene LibraryProtein Binding

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being