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NHE6-Depletion Corrects ApoE4-Mediated Synaptic Impairments and Reduces Amyloid Plaque Load

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.03.22.436385Source: DataRank Database

NHE6-Depletion Corrects ApoE4-Mediated Synaptic Impairments and Reduces Amyloid Plaque Load is a research paper published in bioRxiv (Cold Spring Harbor Laboratory) (2021). On theSindex it has a DataRank of 0. It has been cited 1 time.

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (5 grants)OA: greenTopics (34)IDs (PubMed, OpenAlex)

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Authors (11)

Xunde Xian ORCID,Connie Wong ORCID,Murat S. Durakoglugil ORCID,Gordon C Werthmann,Takaomi SAIDO

Live enrichment

PubMed:21097893 OpenAlex:https://openalex.org/W3139037885

National Institutes of Health

Grant: 5R37HL063762-15

Metabolism of the VLDL receptor and ApoE receptor 2

National Institutes of Health

Grant: 5R01NS108115-02

Validation of Modulators of PGRN as Novel Therapeutics for Frontotemporal Dementi

National Institutes of Health

Grant: 1R01NS093382-01A1

Molecular Basis of Synaptic Suppression by ApoE

National Institutes of Health

Grant: 1RF1AG053391-01

Physiology and Pathophysiology of Apolipoprotein E receptor-2 splicing in Alzheimer's disease

National Institutes of Health

Grant: 1F31AG067708-01

NHE6: A Novel Rational Target For Alzheimer's Disease

greenLicense: https://www.biorxiv.org/about/FAQ#license

repositoryhttps://www.biorxiv.org/content/biorxiv/early/2021/07/09/2021.03.22.436385.full.pdf

publisherhttps://syndication.highwire.org/content/doi/10.1101/2021.03.22.436385

repositoryhttps://doi.org/10.1101/2021.03.22.436385

https://europepmc.org/articles/pmc8547963?pdf=render

Fields of Study

Alzheimer's disease research and treatmentsCalcium signaling and nucleotide metabolismIon Transport and Channel Regulation0301 basic medicine0303 health sciences03 medical and health sciences

Keywords

EndosomeEndocytosisAmyloid (mycology)Apolipoprotein ESynaptic vesicleSynapseHomeostasisMaleMice, KnockoutNHE6Sodium-Hydrogen ExchangersQH301-705.5ScienceQApolipoprotein E4neurodegenerationRPlaque, AmyloidAlzheimer'sMicetraffickingMedicineAnimalsFemaleBiology (General)Low Density Lipoprotein Receptor-Related Protein-1ApoENeuroscience