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Depleting Hypothalamic Somatostatinergic Neurons Recapitulates Diabetic Phenotypes in Brain, Bone Marrow, Adipose, and Retina

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.03.30.437706Source: DataRank Database

Depleting Hypothalamic Somatostatinergic Neurons Recapitulates Diabetic Phenotypes in Brain, Bone Marrow, Adipose, and Retina is a research paper published in bioRxiv (Cold Spring Harbor Laboratory) (2021). On theSindex it has a DataRank of 0.

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Enrichment:Funding (6 grants)OA: greenTopics (46)IDs (PubMed, OpenAlex)SDGs (2)

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Authors (11)

Robert F. Rosencrans ORCID,Raluca Bugescu,Cristiano Pedrozo Vieira ORCID,Ping Hu ORCID,Yvonne Adu-Agyeiwaah ORCID

Live enrichment

PubMed:26207759 OpenAlex:https://openalex.org/W3149303044

National Institutes of Health

Grant: 5R01EY012601-09

Endothelial precursor dysfunction in development of diabetic acellular capillary

National Institutes of Health

Grant: 5T32GM008361-26

Medical Scientist Training Program

National Institutes of Health

Grant: 1U24DK059637-01

CORE--METABOLIC PATHOPHYSIOLOGY

National Institutes of Health

Grant: 5R01EY028037-04

Somatostatin blockade of CNS autonomic hyperactivity for treatment of diabetic retinopathy

National Institutes of Health

Grant: 5R01EY028858-03

ACE2 Modulates the Bone Marrow- Gut Axis in Diabetic Retinopathy

National Institutes of Health

Grant: 5R01EY025383-04

LXR as a Novel Therapeutic Target in Diabetic Retinopathy

greenLicense: cc-by-nc-nd

repositoryhttps://www.biorxiv.org/content/biorxiv/early/2021/03/31/2021.03.30.437706.full.pdf

publisherhttps://syndication.highwire.org/content/doi/10.1101/2021.03.30.437706

repositoryhttps://doi.org/10.1101/2021.03.30.437706

https://doi.org/10.1007/s00125-021-05549-6

Fields of Study

Regulation of Appetite and ObesityNeuroinflammation and Neurodegeneration MechanismsReceptor Mechanisms and Signaling0301 basic medicine03 medical and health sciences0303 health sciences

Keywords

EndocrinologyInternal medicineInflammationAdipose tissueBiologyMicrogliaNeuropeptide Y receptorHypothalamusMedicineReceptorNeuropeptideNeuroimmunologyClinical SciencesInbred C57BLReal-Time Polymerase Chain ReactionRetinaPaediatrics and Reproductive MedicineEndocrinology & MetabolismMiceBone MarrowDiabetes MellitusElectroretinography2.1 Biological and endogenous factorsAnimalsDiphtheria ToxinAetiologyMetabolic and endocrineNeuronsDiabetesNeurosciencesBrainElectroretinogramFlow CytometryImmunohistochemistryMice, Inbred C57BLDiabetes Mellitus, Type 2Public Health and Health ServicesMonocytosisSomatostatinType 2

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being