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Combined Inhibition of AKT and KIT Restores Expression of Programmed Cell Death 4 (PDCD4) in Gastrointestinal Stromal Tumor

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.04.13.439680Source: DataRank Database

Combined Inhibition of AKT and KIT Restores Expression of Programmed Cell Death 4 (PDCD4) in Gastrointestinal Stromal Tumor is a research paper published in bioRxiv (Cold Spring Harbor Laboratory) (2021). On theSindex it has a DataRank of 0.

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Enrichment:Funding (3 grants)OA: greenTopics (25)IDs (PubMed, OpenAlex)SDGs (2)

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Authors (14)

Shalina Joshi,Shuai Ye ORCID,Martin G. Belinsky ORCID,Dinara Sharipova,Jeffrey M. Farma ORCID

Live enrichment

PubMed:19965766 OpenAlex:https://openalex.org/W3156668717

National Institutes of Health

Grant: 5P30CA006927-49

Transgenic Mouse

National Institutes of Health

Grant: 5R01CA212662-02

Exploiting vulnerabilities in GIST using novel combination therapies

National Institutes of Health

Grant: 4R00CA158065-03

ZNF-Mediated Resistance to Imatinib Mesylate in Gastrointestinal Stromal Tumor

greenLicense: https://www.biorxiv.org/about/FAQ#license

repositoryhttps://www.biorxiv.org/content/biorxiv/early/2021/04/14/2021.04.13.439680.full.pdf

publisherhttps://syndication.highwire.org/content/doi/10.1101/2021.04.13.439680

repositoryhttps://doi.org/10.1101/2021.04.13.439680

https://doi.org/10.3390/cancers13153699

Fields of Study

Gastrointestinal Tumor Research and TreatmentSarcoma Diagnosis and TreatmentPlatelet Disorders and Treatments0301 basic medicine03 medical and health sciences0302 clinical medicine

Keywords

GiSTProtein kinase BCancer researchPI3K/AKT/mTOR pathwayStromal cellDownregulation and upregulationImatinibImatinib mesylateCell cultureChemistrySignal transductionMedicineBiologyCell biologyBiochemistryPDCD4AKTgastrointestinal stromal tumorArticle

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being