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TIGER: The gene expression regulatory variation landscape of human pancreatic islets

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.05.26.445616Source: DataRank Database

TIGER: The gene expression regulatory variation landscape of human pancreatic islets is a dataset published in bioRxiv (Cold Spring Harbor Laboratory) (2021). On theSindex it has a DataRank of 0.415, placing it in the top 44.6% of the data-sharing corpus. It has been cited 8 times, with 5 citing works in its 1-hop citation network.

Top 45%percentile

0.415DataRank

Ranks in the top 45% for downstream scientific impact

Data paper Open Access8 citations · 5 citing works in its network

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DataRank reads this dataset's downstream impact straight off the citation graph — no black box, no proprietary weighting. How is this computed?

›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (10 grants)OA: greenTopics (59)IDs (PubMed, OpenAlex)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (1/3)

Dataset classification

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DataRank Breakdown

Base Score 79%Citation Network 21%

Base Score Contribution

0.330

From this paper's citation signal

Citation Network Contribution

0.0851

From 5 citing papers with measurable signal

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Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 5 citers.

NPC1 is required for postnatal islet β cell differentiation by maintaining mitochondria turnover
Theranostics20249 citations72 referencesContributes 0.032
Genome-wide association study for circulating metabolic traits in 619,372 individuals
medRxiv202417 citations94 referencesContributes 0.031
Expression Silencing of Mitogen-Activated Protein Kinase 8 Interacting Protein-1 Conferred Its Role in Pancreatic β-Cell Physiology and Insulin Secretion
Metabolites20232 citations56 referencesContributes 0.020
Loss of Secretory Pathway Ca 2+ ATPase (SPCA1) Impairs Insulin Secretion and Reduces Autophagy in the Pancreatic Islet
bioRxiv (Cold Spring Harbor Laboratory)20211 citations61 referencesContributes 0.011
Uncovering the multivariate genetic architecture of frailty with genomic structural equation modelling
medRxiv20242 citations171 referencesContributes 0.006

Authors (30)

Anthony Piron ORCID,Ignasi Morán ORCID,Marta Guindo-Martínez ORCID,Sílvia Bonàs‐Guarch ORCID,Goutham Atla ORCID

Live enrichment

PubMed:19022398 OpenAlex:https://openalex.org/W3205100486

Wellcome Trust

Grant: 200837

Defining mechanisms for pancreatic beta-cell dysfunction in type 2 diabetes

National Institutes of Health

Grant: 7U01DK105535-06

Integrating genome-scale data to reveal causal mechanisms in type 2 diabetes

Wellcome Trust

Grant: 106130

A systematic approach to understanding the biology underpinning GWAS hits.

European Commission

Grant: 789055

Expanding the genetic etiological and diagnostic spectrum of monogenic diabetes mellitus

European Commission

Grant: 115881

Assessing risk and progression of prediabetes and type 2 diabetes to enable disease modification - Sofia ref.: 115881

Wellcome Trust

Grant: 095101

Bridging the gap from type 2 diabetes genetics to functional mechanisms of disease.

European Commission

Grant: 667191

Development of a systems biomedicine approach for risk identification, prevention and treatment of type 2 diabetes

UK Research and Innovation

Grant: MR/L02036X/1

Targeting etiologic molecular mechanisms to treat human diabetes

National Institutes of Health

Grant: 5U01DK085545-02

Identifying variants causal for Type 2 Diabetes in Major human populations

Wellcome Trust

Grant: 101033

Understanding regulatory variation in human diabetes.

greenLicense: cc-by-nc-nd

repositoryhttps://www.biorxiv.org/content/biorxiv/early/2021/05/27/2021.05.26.445616.full.pdf

publisherhttps://syndication.highwire.org/content/doi/10.1101/2021.05.26.445616

repositoryhttps://doi.org/10.1101/2021.05.26.445616

https://doi.org/10.1016/j.celrep.2021.109807

Fields of Study

Pancreatic function and diabetesGenetic Associations and EpidemiologyGenetic Mapping and Diversity in Plants and Animals0301 basic medicine0303 health sciences03 medical and health sciences

Keywords

Expression quantitative trait lociBiologyIsletGenotypingHuman genetic variationGenome-wide association studyQuantitative trait locusComputational biologyGeneticsPancreatic isletsAlleleGenotypeGeneGenetic variationSingle-nucleotide polymorphismHuman genomeDiabetes mellitusEndocrinologyGenomeEpigenomicsEpigenomeGene FrequencyAllele-specific expressionÀrees temàtiques de la UPC::Informàtica::Aplicacions de la informàtica::BioinformàticaDatabases, GeneticCyclin D2expression quantitative trait locus (eQTL)Genòmica -- InformàticaGenome-wide association study (GWAS)DiabetisType 2 diabetesGenomicsSciences bio-médicales et agricolesBeta cellEuropePhenotypeQuantitative Trait Loci610Zinc Transporter 8Article576Regulatory variationIslets of LangerhansPàncrees -- MalaltiesHumansGenetic Predisposition to Diseaseallele-specific expression; beta cell; epigenomics; expression quantitative trait locus (eQTL); genome-wide association study (GWAS); pancreatic islets; regulatory variation; RNA-seq; transcriptome; type 2 diabetesGene expression.Diabetes Mellitus, Type 2Gene expressionRNA-seqTranscriptomeGenètica

Sustainable Development Goals

SDG 3: 3. Good health