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Gene-teratogen interactions influence the penetrance of birth defects by altering Hedgehog signaling strength

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.06.23.449683Source: DataRank Database

Gene-teratogen interactions influence the penetrance of birth defects by altering Hedgehog signaling strength is a research paper published in bioRxiv (Cold Spring Harbor Laboratory) (2021). On theSindex it has a DataRank of 0. It has been cited 1 time.

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Enrichment:Funding (4 grants)OA: greenTopics (33)IDs (PubMed, OpenAlex)

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Authors (14)

Cullen B. Young ORCID,Ganesh V. Pusapati ORCID,F. Hernán Espinoza ORCID,Chandni Patel ORCID,Francis Beckert

Live enrichment

PubMed:19162232 OpenAlex:https://openalex.org/W3174534280

National Institutes of Health

Grant: 5R35GM118082-04

Biochemical and cell biological mechanisms of signal transduction through the Hedgehog pathway

National Institutes of Health

Grant: 3R01HL142788-03S1

Mechanism of LV Hypoplasia in Hypoplastic Left Heart Syndrome Supplement

National Institutes of Health

Grant: 5R01HL157103-04

A protein traffic control system that regulates left-right patterning and heart development

National Institutes of Health

Grant: 5R01HL132024-04

Modeling the complex genetics of congenital heart disease in mice

greenLicense: cc-by-nc

repositoryhttps://www.biorxiv.org/content/biorxiv/early/2021/06/24/2021.06.23.449683.full.pdf

publisherhttps://syndication.highwire.org/content/doi/10.1101/2021.06.23.449683

repositoryhttps://doi.org/10.1101/2021.06.23.449683

https://doi.org/10.1242/dev.199867

Fields of Study

Hedgehog Signaling Pathway StudiesEpigenetics and DNA MethylationRenal and related cancers0301 basic medicine0303 health sciences03 medical and health sciences

Keywords

PenetranceTeratologySmoothenedHedgehogBiologySonic hedgehogHedgehog signaling pathwayGeneticsIn uteroSignal transductionCell biologyFetusPregnancyPhenotypeGeneAbnormalities, Drug-InducedSmoothened ReceptorMice, Inbred C57BLMiceHEK293 CellsNIH 3T3 CellsAnimalsHumansGene-Environment InteractionHedgehog ProteinsCells, CulturedResearch Article