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HIV-1 envelope glycoproteins proteolytic cleavage protects infected cells from ADCC mediated by plasma from infected individuals

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.10.26.465908Source: DataRank Database

HIV-1 envelope glycoproteins proteolytic cleavage protects infected cells from ADCC mediated by plasma from infected individuals is a research paper published in bioRxiv (Cold Spring Harbor Laboratory) (2021). On theSindex it has a DataRank of 0. It has been cited 4 times.

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Open Access4 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (9 grants)OA: greenTopics (48)IDs (PubMed, OpenAlex)SDGs (2)

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Findable (1/2)

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Accessible (1/2)

Open Access

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Reusable (0/3)

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Authors (7)

Halima Medjahed,Dani Vézina ORCID,Hung-Ching Chen ORCID,Beatrice H. Hahn ORCID,Amos B. Smith ORCID

Live enrichment

PubMed:19162232 OpenAlex:https://openalex.org/W3211215366

National Institutes of Health

Grant: 1R01AI129769-01

Unlocking Env: A New Strategy for a Functional Cure Through Antibody-Dependent Cell-Mediated Cytotoxicity

National Institutes of Health

Grant: 5R01AI162646-03

Characterizing the viral and host effector mechanisms that govern HIV-1 rebound

National Institutes of Health

Grant: 5UM1AI164562-03

Enterprise for Research and Advocacy to Stop and Eradicate HIV (ERASE-HIV)

National Institutes of Health

Grant: 3P01GM056550-16S1

Structure-Based Antagonism of HIV-1 Envelope Function in Cell Entry

National Institutes of Health

Grant: 1UM1AI164562-01

Enterprise for Research and Advocacy to Stop and Eradicate HIV (ERASE-HIV)

Canadian Institutes of Health Research

Grant: unidentified

unidentified

National Institutes of Health

Grant: 5R01AI148379-02

Assessing ADCC and Fc-mediated Protection against HIV

National Institutes of Health

Grant: 1R01AI150322-01

Characterizing HIV-1 Env conformations susceptible to attack by non-neutralizing antibodies

National Institutes of Health

Grant: 5UM1AI164570-03

BEAT-HIV: Delaney Collaboratory to Cure HIV-1 Infection by Combination Immunotherapy

greenLicense: cc-by

repositoryhttps://www.biorxiv.org/content/biorxiv/early/2021/10/26/2021.10.26.465908.full.pdf

publisherhttps://syndication.highwire.org/content/doi/10.1101/2021.10.26.465908

repositoryhttps://doi.org/10.1101/2021.10.26.465908

https://doi.org/10.3390/v13112236

Fields of Study

HIV Research and TreatmentComplement system in diseasesImmune Cell Function and Interaction0301 basic medicine03 medical and health sciences0303 health sciences

Keywords

Antibody-dependent cell-mediated cytotoxicityFurinGlycoproteinCleavage (geology)EpitopeCell biologyEndoplasmic reticulumViral envelopeChemistryEndocytic cycleVirologyAntibodyBiologyMolecular biologyEndocytosisIn vitroCellCytotoxicityBiochemistryImmunologyCD4-Positive T-LymphocytesProtein ConformationnnAbsAmino Acid MotifsHIV InfectionsHIV AntibodiesMicrobiologyHIV Envelope Protein gp160Humansfurin cleavage siteCommunicationCell MembraneAntibody-Dependent Cell CytotoxicityVirionenv Gene Products, Human Immunodeficiency VirusQR1-502CD4 mimeticsTemsavirMutationProteolysisHIV-1Env glycoprotein

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being