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Ronapreve (REGN-CoV; casirivimab and imdevimab) reduces the viral burden and alters the pulmonary response to the SARS-CoV-2 Delta variant (B.1.617.2) in K18-hACE2 mice using an experimental design reflective of a treatment use case

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.01.23.477397Source: DataRank Database

Ronapreve (REGN-CoV; casirivimab and imdevimab) reduces the viral burden and alters the pulmonary response to the SARS-CoV-2 Delta variant (B.1.617.2) in K18-hACE2 mice using an experimental design reflective of a treatment use case is a research paper published in bioRxiv (Cold Spring Harbor Laboratory) (2022). On theSindex it has a DataRank of 0. It has been cited 12 times.

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (18 grants)OA: greenTopics (43)IDs (PubMed, OpenAlex)SDGs (1)

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Open Access

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Authors (17)

Anja Kipar ORCID,Joanne Sharp ORCID,Edyta Kijak,Joanne Herriott ORCID,Megan Neary ORCID

Live enrichment

PubMed:35118468 OpenAlex:https://openalex.org/W4206971782

National Institutes of Health

Grant: 1F32AI010145-01

FUNCTIONAL ANALYSIS OF RNS, A VIRULENCE REGULATOR

UK Research and Innovation

Grant: EP/S012265/1

An Injectable Implant Providing Long-Acting Drug Delivery for the Treatment of Chronic disease

UK Research and Innovation

Grant: BB/R018863/1

BPIFA1: from anti-viral peptide to immunomodulator

National Institutes of Health

Grant: 5R24AI118397-10

The Long-Acting/Extended Release Antiretroviral Resource Program (LEAP)

Wellcome Trust

Grant: 222489

Design and implementation of a translational drug development platform for COVID-19 to generate preclinical evidence in support of treatment arms of the ANTICOV clinical trial

UK Research and Innovation

Grant: EP/R024804/1

New Branched Polymers Excipients and Emulsions for Enhanced Drug Delivery

UK Research and Innovation

Grant: MR/W005611/1

G2P-UK; A National Virology Consortium to address phenotypic consequences of SARSCoV-2 genomic variation

UK Research and Innovation

Grant: BB/N022505/1

China Partnering Award: Exchange of vaccine technology for delivery of oral vaccines to mucosal surfaces

UK Research and Innovation

Grant: MR/R010145/1

Targeting the RNA helicase, UAP56: understanding KSHV RNA processing mechanisms to novel antiviral approaches

Swiss National Science Foundation

Grant: 213289

Direct and indirect effects of SARS-CoV-2 on the brain – a translational approach to Long COVID Syndrome

European Commission

Grant: 101057553

Decision support for prediction and management of Long Covid Syndrome (LCS)

Swiss National Science Foundation

Grant: 101057

Relazioni a livello molecolare e cellulare tra parassiti ed ospiti intermedi o definitivi (possibili vettori di interesse biomedico e biotecnologico)

National Institutes of Health

Grant: 5R01ES012265-09

Role and Regulation of INrf2

UK Research and Innovation

Grant: BB/R00904X/1

The role of LC3-associated phagocytosis during virus infection

National Institutes of Health

Grant: 5R01AI134091-05

Long acting NRTI therapies for HIV

NIAID NIH HHS

Grant: R01 AI134091

NIAID NIH HHS

Grant: R24 AI118397

Wellcome Trust

greenLicense: cc-by-nd

repositoryhttps://www.biorxiv.org/content/biorxiv/early/2023/03/09/2022.01.23.477397.full.pdf

publisherhttps://syndication.highwire.org/content/doi/10.1101/2022.01.23.477397

repositoryhttps://doi.org/10.1101/2022.01.23.477397

repositoryhttps://pubmed.ncbi.nlm.nih.gov/35118468

Fields of Study

SARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research Studiesvaccines and immunoinformatics approaches

Keywords

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Coronavirus disease 2019 (COVID-19)Virology2019-20 coronavirus outbreakDeltaMedicinePhysicsInternal medicine10184 Institute of Veterinary PathologyAntibodies, ViralVirus ReplicationAntibodies, Monoclonal, HumanizedMicrobiologyAntiviral Agents2726 Microbiology (medical)Article1307 Cell BiologyMice1311 Genetics2400 General Immunology and Microbiologypreclinical PK/PDAnimalsHumansLungmAbSARS-CoV-2COVID-19Antibodies, Monoclonal1314 Physiology2725 Infectious DiseasesViral LoadAntibodies, NeutralizingQR1-502COVID-19 Drug TreatmentDisease Models, Animal570 Life sciences; biologyFemaleAngiotensin-Converting Enzyme 22303 EcologyResearch Article

Sustainable Development Goals

SDG 0: Good health and well-being