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Cognitive Deficits and Altered Cholinergic Innervation in Young Adult Mice Carrying a Parkinson’s Disease LRRK2-G2019S Knockin Mutation

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.01.26.477929Source: DataRank Database

Cognitive Deficits and Altered Cholinergic Innervation in Young Adult Mice Carrying a Parkinson’s Disease LRRK2-G2019S Knockin Mutation is a research paper published in bioRxiv (Cold Spring Harbor Laboratory) (2022). On theSindex it has a DataRank of 0.

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Enrichment:Funding (2 grants)OA: greenTopics (28)IDs (PubMed, OpenAlex)SDGs (1)

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Authors (5)

Alexander Tielemans ORCID,Mark G. Baxter ORCID,Deanna L. Benson ORCID,George W. Huntley ORCID,Ayan Hussein ORCID

Live enrichment

PubMed:19910364 OpenAlex:https://openalex.org/W4210605218

National Institutes of Health

Grant: 1F31NS117089-01

The Effect of Parkinson's-linked LRRK2-G2019S Mutation on Corticostriatal-based Cognition

National Institutes of Health

Grant: 5R01NS107512-02

Impact of human disease-causing mutation on striatal synaptic and behavioral plasticity

greenLicense: cc-by-nc-nd

repositoryhttps://www.biorxiv.org/content/biorxiv/early/2022/01/26/2022.01.26.477929.full.pdf

publisherhttps://syndication.highwire.org/content/doi/10.1101/2022.01.26.477929

repositoryhttps://doi.org/10.1101/2022.01.26.477929

https://doi.org/10.1016/j.expneurol.2022.114145

Fields of Study

Parkinson's Disease Mechanisms and TreatmentsCholinesterase and Neurodegenerative DiseasesNeurological disorders and treatments0301 basic medicine03 medical and health sciences0302 clinical medicine

Keywords

Cognitive flexibilityCholinergicLRRK2NeurosciencePsychologyCognitionParkinson's diseaseStriatumCholinergic neuronDopamineDiseaseMedicineInternal medicineMaleCholinergic AgentsParkinson DiseaseLeucine-Rich Repeat Serine-Threonine Protein Kinase-2MiceMutationAcetylcholinesteraseAnimalsCognitive Dysfunction

Sustainable Development Goals

SDG 3: 3. Good health