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Antisense modulation of IL7R splicing to control sIL7R expression in human CD4 + T cells

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.02.22.481529Source: DataRank Database

Antisense modulation of IL7R splicing to control sIL7R expression in human CD4 + T cells is a research paper published in bioRxiv (Cold Spring Harbor Laboratory) (2022). On theSindex it has a DataRank of 0.

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (3 grants)OA: greenTopics (32)IDs (PubMed, OpenAlex)SDGs (2)

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Authors (5)

Debbie Kennedy-Boone,Geraldine Schott,Shelton S. Bradrick ORCID,Mariano A. García-Blanco ORCID,Gaddiel Galarza-Muñoz ORCID

Live enrichment

PubMed:19162232 OpenAlex:https://openalex.org/W4213437105

National Institutes of Health

Grant: 1R41AI141323-01A1

Development of a novel accurate therapy for Multiple Sclerosis

National Institutes of Health

Grant: 1R41AI149920-01

Determination of optimal antisense oligonucleotide chemistry for efficient and safe splicing modulation in T cells

National Institutes of Health

Grant: 1R43AI143319-01

Novel accurate therapy for Multiple Sclerosis: Optimization of antisense oligonucleotides delivery and functionality in primary T cells

greenLicense: cc-by-nc-nd

repositoryhttps://www.biorxiv.org/content/biorxiv/early/2022/02/24/2022.02.22.481529.full.pdf

publisherhttps://syndication.highwire.org/content/doi/10.1101/2022.02.22.481529

repositoryhttps://doi.org/10.1101/2022.02.22.481529

https://doi.org/10.1261/rna.079137.122

Fields of Study

Immune Cell Function and InteractionViral Infections and Immunology ResearchRNA Research and Splicing0301 basic medicine0303 health sciences03 medical and health sciences

Keywords

ExonInterleukin-7 receptorDownregulation and upregulationMultiple sclerosisRNA splicingBiologyCancer researchAlternative splicingImmunologyMolecular biologyGeneticsT cellImmune systemGeneIL-2 receptorRNACD4-Positive T-LymphocytesReceptors, Interleukin-7T-LymphocytesExonsOligonucleotides, AntisenseArticleInterleukin-7 Receptor alpha SubunitMiceAnimalsHumans

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Reduced inequalities