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Dependence on a variable residue limits the breadth of an HIV MPER neutralizing antibody, despite convergent evolution with broadly neutralizing antibodies

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.03.18.484856Source: DataRank Database

Dependence on a variable residue limits the breadth of an HIV MPER neutralizing antibody, despite convergent evolution with broadly neutralizing antibodies is a research paper published in bioRxiv (Cold Spring Harbor Laboratory) (2022). On theSindex it has a DataRank of 0. It has been cited 1 time.

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (2 grants)OA: greenTopics (46)IDs (PubMed, OpenAlex)SDGs (2)

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Authors (12)

Prudence Kgagudi,Nonkululeko Mzindle,Elin S. Gray ORCID,Thandeka Moyo-Gwete ORCID,Bronwen E. Lambson ORCID

Live enrichment

PubMed:19162232 OpenAlex:https://openalex.org/W4220825212

National Institutes of Health

Grant: 3U19AI051794-04S3

Starting TB and AntiRetroviral Therapy

National Institutes of Health

Grant: 5U01AI136677-04

Immunoglobulin gene diversity in an African population and impact on antibody function in HIV infection

greenLicense: cc-by

repositoryhttps://www.biorxiv.org/content/biorxiv/early/2022/03/19/2022.03.18.484856.full.pdf

publisherhttps://syndication.highwire.org/content/doi/10.1101/2022.03.18.484856

repositoryhttps://doi.org/10.1101/2022.03.18.484856

https://doi.org/10.1371/journal.ppat.1010450

Fields of Study

HIV Research and TreatmentHIV/AIDS drug development and treatmentImmune Cell Function and Interaction0301 basic medicine03 medical and health sciences

Keywords

BiologyEpitopeAntibodyNeutralizationPotencyGp41Monoclonal antibodyVirologyNeutralizing antibodyGermlineGeneMutagenesisGeneticsMutationIn vitro570QH301-705.5DiseasesHIV InfectionsvirusGermline-targeting immunogensHIV Antibodiesantibodies (bNAbs)EpitopesMedicine and Health SciencesHumansBiology (General)Amino AcidsAIDS VaccinesHIVAntibodies, MonoclonalRC581-607Antibodies, NeutralizingHIV Envelope Protein gp41membrane-proximal external region (MPER)Virus DiseasesHIV-1SolventsImmunologic diseases. AllergyBroadly Neutralizing AntibodiesResearch Article

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being