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Structure-based Evolution of G protein-biased μ-opioid Receptor Agonists

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.03.22.485330Source: DataRank Database

Structure-based Evolution of G protein-biased μ-opioid Receptor Agonists is a research paper published in bioRxiv (Cold Spring Harbor Laboratory) (2022). On theSindex it has a DataRank of 0.

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (4 grants)OA: greenTopics (30)IDs (PubMed, OpenAlex)

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Authors (10)

Florian Hetzer,Weijiao Huang ORCID,Qianhui Qu ORCID,Justin Meyerowitz ORCID,Jonas Kaindl ORCID

Live enrichment

PubMed:19162232 OpenAlex:https://openalex.org/W4221091137

Deutsche Forschungsgemeinschaft

Grant: unidentified

unidentified

National Institutes of Health

Grant: 5R37DA036246-06

Structural Basis of Opioid Receptor Function

Deutsche Forschungsgemeinschaft

Grant: 222125149/GRK 1910

Medicinal Chemistry of Selective GPCR Ligands

National Institutes of Health

Grant: 2T32GM089626-11

Research in Anesthesia Training Program (ReAP)

greenLicense: cc-by-nd

repositoryhttps://www.biorxiv.org/content/biorxiv/early/2022/03/25/2022.03.22.485330.full.pdf

publisherhttps://syndication.highwire.org/content/doi/10.1101/2022.03.22.485330

repositoryhttps://doi.org/10.1101/2022.03.22.485330

https://doi.org/10.1002/anie.202200269

Fields of Study

Receptor Mechanisms and SignalingMass Spectrometry Techniques and ApplicationsNeuropeptides and Animal Physiology0301 basic medicine0303 health sciences03 medical and health sciences

Keywords

AgonistDocking (animal)LipophilicityG proteinG protein-coupled receptorReceptorChemistryArrestinSignal transductionOpioid receptorOpioidComputational biologyPharmacologyBioinformaticsCell biologyBiophysicsBiologyBiochemistryMedicineAnalgesics, OpioidGTP-Binding ProteinsReceptors, Opioid, muCommunicationsbeta-Arrestins