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Dynamic allostery in substrate binding by human thymidylate synthase

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.05.16.492048Source: DataRank Database

Dynamic allostery in substrate binding by human thymidylate synthase is a research paper published in bioRxiv (Cold Spring Harbor Laboratory) (2022). On theSindex it has a DataRank of 0. It has been cited 6 times.

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Open Access6 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (3 grants)OA: greenTopics (36)IDs (PubMed, OpenAlex)SDGs (1)

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Findable (1/2)

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Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (3)

Paul J. Sapienza ORCID,Andrew L. Lee ORCID,Jeffrey P. Bonin ORCID

Live enrichment

PubMed:21097893 OpenAlex:https://openalex.org/W4280631508

National Institutes of Health

Grant: 5P41GM111135-04

Center for Biomolecular NMR Data Processing and Analysis

National Institutes of Health

Grant: 3P30CA016086-42S2

Cancer Center Support Grant

National Institutes of Health

Grant: 3R01GM083059-04S1

Intra- and Intermolecular Dynamics of Dihydrofolate Reductase

greenLicense: cc-by

repositoryhttps://www.biorxiv.org/content/biorxiv/early/2022/05/16/2022.05.16.492048.full.pdf

publisherhttps://syndication.highwire.org/content/doi/10.1101/2022.05.16.492048

repositoryhttps://doi.org/10.1101/2022.05.16.492048

repositoryhttps://doi.org/10.17615/z0f4-rj28

Fields of Study

Biochemical and Molecular ResearchEnzyme Structure and FunctionProtein Structure and Dynamics0301 basic medicine0303 health sciences03 medical and health sciences

Keywords

CooperativityAllosteric regulationCooperative bindingChemistrySubstrate (aquarium)EnzymeAllosteric enzymeThymidylate synthaseStereochemistryNucleotideBiophysicsBinding siteBiochemistryBiologyconformational entropyallosteryQH301-705.5NucleotidesProtein ConformationScienceStructural Biology and Molecular BiophysicsQRMolecular ConformationNMRprotein dynamicsMedicineHumansBiology (General)Protein Binding

Sustainable Development Goals

SDG 3: 3. Good health