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Lowering of circulating sclerostin may increase risk of atherosclerosis and its risk factors: evidence from a genome-wide association meta-analysis followed by Mendelian randomization

medRxiv(2022)10.1101/2022.06.13.22275915Source: DataRank Database

Lowering of circulating sclerostin may increase risk of atherosclerosis and its risk factors: evidence from a genome-wide association meta-analysis followed by Mendelian randomization is a research paper published in medRxiv (2022). On theSindex it has a DataRank of 0.312. It has been cited 7 times.

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0.312DataRank · unranked

Scored on demand from live citation data

Open Access7 citations

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (16 grants)OA: greenTopics (60)IDs (PubMed, OpenAlex)Annotations (2)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 100%Citation Network 0%

Base Score Contribution

0.312

From this paper's citation signal

Citation Network Contribution

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Authors (37)

Eleanor Wheeler ORCID,Maik Pietzner ORCID,Till F. M. Andlauer ORCID,Michelle S. Yau ORCID,April Hartley ORCID

Live enrichment

PubMed:26207759 OpenAlex:https://openalex.org/W4283028882

Wellcome Trust

Grant: WT102215

Wellcome Trust

Grant: WT088806

Wellcome Trust

Grant: 20378/Z/16/Z

Wellcome Trust

Grant: 102215

The Avon Longitudinal Study for Parents and Children: An international resource for population genomic and lifecourse epidemiology. Core programme support 2014-2019.

UK Research and Innovation

Grant: MC_UU_00011/1

Mendelian randomization to hypothesis-free causal inference

National Institutes of Health

Grant: 2R01HL105756-07

CHARGE consortium: gene discovery for CVD and aging phenotypes

National Institutes of Health

Grant: 3R01HL142809-03S1

The Role of Histone Deacetylase 9 in Vascular Calcification

UK Research and Innovation

Grant: G1001357

The menopausal transition and healthy ageing and wellbeing

Wellcome Trust

Grant: unidentified

unidentified

National Institutes of Health

Grant: 5P30DK072488-02

CORE--ADIPOSE TISSUE BIOLOGY AND BASIC MECHANISMS

Wellcome Trust

Grant: 088806

Genome-wide association study of maternal pregnancy phenotypes and later-life maternal and offspring vascular and metabolic phenotypes.

European Commission

Grant: 848146

A high-dimensional approach for unwinding immune-metabolic causes of cardiovascular disease-depression multimorbidities

Wellcome Trust

Grant: 092830

The relationship of the menopausal transition to healthy aging and chronic disease risk.

National Institutes of Health

Grant: 5R01HL146860-02

Whole-genome sequencing analysis of coronary atherosclerosis and related traits

National Institutes of Health

Grant: 5R01HL159514-03

Characterization of Functional Iron Deficiency and Repletion in Heart Failure with Preserved Ejection Fraction

National Institutes of Health

Grant: 5R01AR075356-03

Systemic contribution of age-associated epigenetic mechanisms to osteoarthritis

greenLicense: cc-by

repositoryhttps://www.medrxiv.org/content/medrxiv/early/2022/06/16/2022.06.13.22275915.full.pdf

publisherhttps://syndication.highwire.org/content/doi/10.1101/2022.06.13.22275915

repositoryhttps://doi.org/10.1101/2022.06.13.22275915

repositoryhttps://www.repository.cam.ac.uk/handle/1810/349242

Fields of Study

Genetic Associations and EpidemiologyBone health and osteoporosis researchLiver Disease Diagnosis and Treatment0301 basic medicine03 medical and health sciences0303 health sciences

Keywords

SclerostinMendelian randomizationInternal medicineMedicineGenome-wide association studySingle-nucleotide polymorphismOdds ratioEndocrinologyDiabetes mellitusBioinformaticsGeneticsBiologyGenotypeGenetic variantsGeneAgingVDP::Medisinsk molekylærbiologi: 711VDP::Medisinsk genetikk: 714VDP::Medisinsk biokjemi: 726VDP::Molekylærbiologi: 473ImmunologyMyocardial Infarction610Diseases32 Biomedical and Clinical SciencesEndocrine System DiseasesCardiovascularPolymorphism, Single Nucleotide/dk/atira/pure/core/keywords/population_health_SRIRheumatologySDG 3 - Good Health and Well-beingRisk FactorsHealth Sciences616OsteoarthritisMedical SpecialtiesMedicine and Health SciencesImmunology and AllergyHumansPolymorphism3202 Clinical SciencesHeart Disease - Coronary Heart DiseasePreventionDiabetesHuman Genome941Single NucleotideMendelian Randomization AnalysisAtherosclerosis3204 ImmunologyHeart Diseaseand MetabolismDiabetes Mellitus, Type 2HypertensionPublic Healthname=Bristol Population Health Science InstituteType 2

Sustainable Development Goals

SDG 0: Good health and well-being

Lowering of circulating sclerostin may increase risk of atherosclerosis and its risk factors: evidence from a genome-wide association meta-analysis followed by Mendelian randomization

FAIR Checklist

DataRank Breakdown

Authors (37)

Funding (16 grants)

Open Access

Topics

Annotations (Europe PMC)