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Characterization of RNA Polymerase II Trigger Loop Mutations using Molecular Dynamics Simulations and Machine Learning

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.08.11.503690Source: DataRank Database

Characterization of RNA Polymerase II Trigger Loop Mutations using Molecular Dynamics Simulations and Machine Learning is a research paper published in bioRxiv (Cold Spring Harbor Laboratory) (2022). On theSindex it has a DataRank of 0. It has been cited 2 times.

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Open Access2 citations

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (4 grants)OA: greenTopics (37)IDs (PubMed, OpenAlex)

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Authors (5)

Bingbing Duan ORCID,Chenxi Qiu ORCID,Craig D. Kaplan ORCID,Michael Feig ORCID,Bercem Dutagaci ORCID

Live enrichment

PubMed:21097893 OpenAlex:https://openalex.org/W4291168211

National Institutes of Health

Grant: 1R35GM144116-01

Mechanisms of RNA Polymerase II transcription

National Institutes of Health

Grant: 5F32GM014116-02

GAP JUNCTIONAL COMMUNICATION IN DROSOPHILA

National Institutes of Health

Grant: 2R35GM126948-06

Modeling and dynamics of biomolecules on cellular scales

National Institutes of Health

Grant: 7R01GM097260-08

Mechanism and Regulation of RNA Polymerase II Elongation

greenLicense: cc-by

repositoryhttps://www.biorxiv.org/content/biorxiv/early/2022/08/12/2022.08.11.503690.full.pdf

publisherhttps://syndication.highwire.org/content/doi/10.1101/2022.08.11.503690

repositoryhttps://doi.org/10.1101/2022.08.11.503690

https://doi.org/10.1371/journal.pcbi.1010999

Fields of Study

RNA and protein synthesis mechanismsGenomics and Chromatin DynamicsBacterial Genetics and Biotechnology0301 basic medicine0303 health sciences03 medical and health sciences

Keywords

PolymeraseMutantRNA polymeraseMolecular dynamicsPhenotypeRNAComputational biologyGeneticsRNA polymerase IIActive siteBiologySaccharomyces cerevisiaeT7 RNA polymeraseTranscription (linguistics)MutationBiophysicsChemistryBiochemistryEnzymeGeneComputational chemistry570Transcription, GeneticQH301-705.5DNA-Directed RNA PolymerasesMolecular Dynamics Simulation540GeneticBiology (General)TranscriptionResearch Article