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APE1 assembles biomolecular condensates to promote the ATR-Chk1 DNA damage response in nucleolus

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.08.22.504787Source: DataRank Database

APE1 assembles biomolecular condensates to promote the ATR-Chk1 DNA damage response in nucleolus is a research paper published in bioRxiv (Cold Spring Harbor Laboratory) (2022). On theSindex it has a DataRank of 0.

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Enrichment:Funding (3 grants)OA: greenTopics (29)IDs (PubMed, OpenAlex)SDGs (2)

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Authors (4)

Haichao Zhao ORCID,Anne McMahon ORCID,Shan Yan ORCID,Jia Li ORCID

Live enrichment

PubMed:19767382 OpenAlex:https://openalex.org/W4292688107

National Institutes of Health

Grant: 5R01CA225637-02

Mechanism of APE1 in DNA damage response

National Institutes of Health

Grant: 5R01CA251141-03

New mouse model of cisplatin-induced AKI and development of prevention therapy

National Institutes of Health

Grant: 5R21ES032966-02

ATM activation by DNA single-strand breaks

greenLicense: cc-by-nc-nd

repositoryhttps://www.biorxiv.org/content/biorxiv/early/2022/08/22/2022.08.22.504787.full.pdf

publisherhttps://syndication.highwire.org/content/doi/10.1101/2022.08.22.504787

repositoryhttps://doi.org/10.1101/2022.08.22.504787

https://doi.org/10.1093/nar/gkac853

Fields of Study

DNA Repair MechanismsPARP inhibition in cancer therapyGenomics and Chromatin Dynamics0301 basic medicine03 medical and health sciences

Keywords

DNA damageNucleolusCell biologyBiologyGene knockdownDNA repairNucleaseDNARNATranscription (linguistics)Molecular biologySmall nucleolar RNALong non-coding RNAGeneticsGeneCytoplasmBiomolecular CondensatesDNA-Binding ProteinsRNA, RibosomalCheckpoint Kinase 1Nuclear ProteinsAtaxia Telangiectasia Mutated ProteinsGenome Integrity, Repair and ReplicationRNA, Small Interfering

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being