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Structure of the Wnt-Frizzled-LRP6 initiation complex reveals the basis for co-receptor discrimination

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.10.21.513178Source: DataRank Database

Structure of the Wnt-Frizzled-LRP6 initiation complex reveals the basis for co-receptor discrimination is a research paper published in bioRxiv (Cold Spring Harbor Laboratory) (2022). On theSindex it has a DataRank of 0. It has been cited 3 times.

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Enrichment:Funding (3 grants)OA: greenTopics (28)IDs (PubMed, OpenAlex)SDGs (1)

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Authors (12)

Sun‐Hee Hwang ORCID,Simon Hansen ORCID,Deepa Waghray,Nan Wang ORCID,Yi Miao ORCID

Live enrichment

PubMed:30945415 OpenAlex:https://openalex.org/W4307282648

National Institutes of Health

Grant: 3P30GM133894-06S1

A Synchrotron Radiation Structural Biology Resource

National Institutes of Health

Grant: 2P30GM124169-06

ALS Efficiently Networking Advanced Beam Line Experiments (ALS-ENABLE)

National Institutes of Health

Grant: 5R01DK115728-02

Structure-based Bioengineering of Wnt Surrogates for Intestinal Stem Cell Biology and Therapy

greenLicense: cc-by

repositoryhttps://www.biorxiv.org/content/biorxiv/early/2022/10/22/2022.10.21.513178.full.pdf

publisherhttps://syndication.highwire.org/content/doi/10.1101/2022.10.21.513178

repositoryhttps://doi.org/10.1101/2022.10.21.513178

https://doi.org/10.1073/pnas.2218238120

Fields of Study

Wnt/β-catenin signaling in development and cancerCancer-related gene regulationPeptidase Inhibition and Analysis0301 basic medicine0303 health sciences03 medical and health sciences

Keywords

FrizzledLRP6Wnt signaling pathwayCell biologyLRP5BiologyReceptorTernary complexBiochemistrySignal transductionCrystallographyCell Membrane610Biological SciencesWnt signalingFrizzled ReceptorsWnt ProteinsLow Density Lipoprotein Receptor-Related Protein-6Protein engineeringStructural biologybeta CateninCryo-EM

Sustainable Development Goals

SDG 0: Reduced inequalities