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Cooperativity between Cas9 and hyperactive AID establishes broad and diversifying mutational footprints in base editors

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.12.03.518995Source: DataRank Database

Cooperativity between Cas9 and hyperactive AID establishes broad and diversifying mutational footprints in base editors is a research paper published in bioRxiv (Cold Spring Harbor Laboratory) (2022). On theSindex it has a DataRank of 0. It has been cited 1 time.

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (4 grants)OA: greenTopics (30)IDs (PubMed, OpenAlex)SDGs (1)

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Interoperable (0/2)

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Authors (10)

Aleksia Barka ORCID,Jasleen Gill ORCID,Juan C. Serrano ORCID,P Bailer ORCID,Jared B. Parker ORCID

Live enrichment

PubMed:30945415 OpenAlex:https://openalex.org/W4310670138

National Institutes of Health

Grant: 5R01GM138908-03

Engineering Efficient and Controllable Base Editors

National Institutes of Health

Grant: 2R01HG010646-05

Ultra low-input epigenetic sequencing with combined enzymatic and long-read technologies

National Institutes of Health

Grant: 1F30HG011578-01

Multiplexing CRISPR/Cas9-based Continuous Evolution for Improved Epigenome Editing

National Institutes of Health

Grant: 2T32GM007170-29

Medical Scientist Training Program

greenLicense: cc-by-nc-nd

repositoryhttps://www.biorxiv.org/content/biorxiv/early/2022/12/04/2022.12.03.518995.full.pdf

publisherhttps://syndication.highwire.org/content/doi/10.1101/2022.12.03.518995

repositoryhttps://doi.org/10.1101/2022.12.03.518995

https://doi.org/10.1093/nar/gkae024

Fields of Study

CRISPR and Genetic EngineeringRNA and protein synthesis mechanismsAdvanced biosensing and bioanalysis techniques0301 basic medicine0303 health sciences03 medical and health sciences

Keywords

CRISPRCas9CooperativityComputational biologyGenome editingDNACooperative bindingBase pairBiologyGuide RNAGeneticsGeneBinding siteGene EditingAICDA (Activation-Induced Cytidine Deaminase)RNA, Guide, CRISPR-Cas SystemsCRISPR-Associated Protein 9Cytidine DeaminaseMutationEscherichia coliHumansAnimalsCRISPR-Cas SystemsSynthetic Biology and Bioengineering

Sustainable Development Goals

SDG 0: Partnerships for the goals