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Deuterated buprenorphine retains pharmacodynamic properties of buprenorphine and resists metabolism to the active metabolite norbuprenorphine in rats

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.12.12.520120Source: DataRank Database

Deuterated buprenorphine retains pharmacodynamic properties of buprenorphine and resists metabolism to the active metabolite norbuprenorphine in rats is a research paper published in bioRxiv (Cold Spring Harbor Laboratory) (2022). On theSindex it has a DataRank of 0.

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Enrichment:Funding (5 grants)OA: greenTopics (23)IDs (PubMed, OpenAlex)SDGs (1)

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Authors (10)

Paloma Salazar,Brian J. Parks,Gregory S. Gorman,Paul L. Prather ORCID,Eric C. Peterson ORCID

Live enrichment

PubMed:21097893 OpenAlex:https://openalex.org/W4311450861

National Institutes of Health

Grant: 1U54TR001629-01A1

Expanding Translational Research in Arkansas

National Institutes of Health

Grant: 5KL2TR000063-05

Arkansas Center for Clinical Translational Research

National Institutes of Health

Grant: 2T32DA022981-06

Translational Training in Addiction

National Institutes of Health

Grant: 5R21DA049585-02

Use of precision deuteration to determine the contribution of norbuprenorphine to buprenorphine-associated neonatal abstinence syndrome

National Institutes of Health

Grant: 3UL1TR003107-02S1

CTSA Admin Supp QAQC - UL1 - Revision

greenLicense: cc-by-nc-nd

repositoryhttps://www.biorxiv.org/content/biorxiv/early/2023/03/30/2022.12.12.520120.full.pdf

repositoryhttps://doi.org/10.1101/2022.12.12.520120

https://doi.org/10.3389/fphar.2023.1123261

https://pubmed.ncbi.nlm.nih.gov/37229250

Fields of Study

Prenatal Substance Exposure EffectsNeuroscience of respiration and sleepOpioid Use Disorder Treatment

Keywords

ChemistryBuprenorphineOpioidPharmacologyMetaboliteReceptorActive metabolitePharmacokineticsRadioligandPotencyPharmacodynamicsBiochemistryMedicineIn vitrodeuterationprenatalopioid use disorderTherapeutics. PharmacologyRM1-950opioid receptors

Sustainable Development Goals

SDG 0: Good health and well-being