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Identification and characterization of small molecule inhibitors of the LINE-1 retrotransposon endonuclease

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.12.29.522256Source: DataRank Database

Identification and characterization of small molecule inhibitors of the LINE-1 retrotransposon endonuclease is a research paper published in bioRxiv (Cold Spring Harbor Laboratory) (2022). On theSindex it has a DataRank of 0.

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (4 grants)OA: greenTopics (34)IDs (PubMed, OpenAlex)

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Authors (3)

G. Jogl ORCID,John M. Sedivy ORCID,Alexandra M. D’Ordine ORCID

Live enrichment

PubMed:19910364 OpenAlex:https://openalex.org/W4313348686

National Institutes of Health

Grant: 5R01AG016694-04

MECHANISMS OF REPLICATIVE SENESCENCE IN CELLS

National Institutes of Health

Grant: 5T32GM007601-07

MOLECULAR AND CELL BIOLOGY

National Institutes of Health

Grant: 3P01AG051449-05S1

Somatic Activation of Retrotransposition: A new Molecular Mechanism of Aging?

National Institutes of Health

Grant: 5P30GM133893-04

The Center for Biomolecular Structure at NSLS-II

greenLicense: CC BY

repositoryhttps://www.biorxiv.org/content/biorxiv/early/2022/12/29/2022.12.29.522256.full.pdf

publisherhttps://syndication.highwire.org/content/doi/10.1101/2022.12.29.522256

repositoryhttps://doi.org/10.1101/2022.12.29.522256

repositoryhttps://www.nature.com/articles/s41467-024-48066-x

Fields of Study

Chromosomal and Genetic VariationsAdvanced biosensing and bioanalysis techniquesCRISPR and Genetic Engineering0301 basic medicine0303 health sciences03 medical and health sciences

Keywords

RetrotransposonBiologyReverse transcriptaseEndonucleaseDNA damageGenomeComputational biologyDrug discoveryInterferonSmall moleculeDNALong terminal repeatCell biologyGeneticsRNABioinformaticsGeneTransposable elementScienceQEndonucleasesArticleSmall Molecule LibrariesLong Interspersed Nucleotide ElementsHumansDeoxyribonuclease IEnzyme InhibitorsCellular Senescence