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APOE4 drives transcriptional heterogeneity and maladaptive immunometabolic responses of astrocytes

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.02.06.527204Source: DataRank Database

APOE4 drives transcriptional heterogeneity and maladaptive immunometabolic responses of astrocytes is a research paper published in bioRxiv (Cold Spring Harbor Laboratory) (2023). On theSindex it has a DataRank of 0. It has been cited 7 times.

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (23 grants)OA: greenTopics (10)IDs (PubMed, OpenAlex)SDGs (1)

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Open Access

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Authors (15)

Holden C. Williams ORCID,Amy A. Gorman,Nicholas A. Devanney ORCID,Douglas A. Harrison ORCID,Adeline E. Walsh ORCID

Live enrichment

PubMed:36798317 OpenAlex:https://openalex.org/W4319443176

National Institutes of Health

Grant: 1R01AG080589-01

APOE Allele Switching as a Therapeutic Approach for Alzheimer's Disease

National Institutes of Health

Grant: 5R01AG062550-03

Changing the energy substrate balance: Does APOE2 promote glucose usage to protect from Alzheimer's Disease?

National Institutes of Health

Grant: 5R01AG068330-02

The metabolic interplay of sleep and Alzheimer's disease

National Institutes of Health

Grant: 5K01AG062683-05

Deciphering isogenic APOE isoform dependent neurodegenerative response in human glia

National Institutes of Health

Grant: 5R01AG070830-04

Contributions of astrocyte RelA signaling in aging-related neurodegenerative sequelae following TBI

National Institutes of Health

Grant: 1R56AG078733-01

Uncovering APOE4 Matrisome endophenotypes using human iPSC-based models

National Institutes of Health

Grant: 1R01AG060056-01

APOE and the PPP: Glucose Metabolism and Oxidative Stress in Alzheimer's Disease

National Institutes of Health

Grant: 1RF1NS118558-01

Inflammatory contributions of astrocytic RelA in comorbid VCID/AD

National Institutes of Health

Grant: 1R21AG068370-01

How does D2-CD33 reduce Alzheimer's disease risk?

National Institutes of Health

Grant: 1RF1AG059717-01

Translating SHIP1 genetics to generate a novel Alzheimer's pharmacologic agent

National Institutes of Health

Grant: 3P30CA177558-01S1

CTRP Supplement

NIA NIH HHS

Grant: R56 AG078733

NIA NIH HHS

Grant: R01 AG070830

NIA NIH HHS

Grant: R01 AG062550

NIA NIH HHS

Grant: K01 AG062683

NIA NIH HHS

Grant: R21 AG068370

NIA NIH HHS

Grant: R01 AG080589

NIA NIH HHS

Grant: P30 AG072947

NIA NIH HHS

Grant: R01 AG068330

NINDS NIH HHS

Grant: RF1 NS118558

NIA NIH HHS

Grant: R01 AG060056

NCI NIH HHS

Grant: P30 CA177558

NIA NIH HHS

Grant: RF1 AG059717

greenLicense: cc-by-nc-nd

repositoryhttps://www.biorxiv.org/content/biorxiv/early/2023/02/06/2023.02.06.527204.full.pdf

publisherhttps://syndication.highwire.org/content/doi/10.1101/2023.02.06.527204

repositoryhttps://doi.org/10.1101/2023.02.06.527204

repositoryhttps://pubmed.ncbi.nlm.nih.gov/36798317

Fields of Study

Neutrophil, Myeloperoxidase and Oxidative MechanismsImmune cells in cancerNeuroinflammation and Neurodegeneration Mechanisms0301 basic medicine0303 health sciences03 medical and health sciences

Keywords

BiologyNeurosciencePsychologyArticle

Sustainable Development Goals

SDG 0: Good health and well-being