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Transient EZH2 suppression by Tazemetostat during in vitro expansion maintains T cell stemness and improves adoptive T cell therapy

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.02.07.527459Source: DataRank Database

Transient EZH2 suppression by Tazemetostat during in vitro expansion maintains T cell stemness and improves adoptive T cell therapy is a research paper published in bioRxiv (Cold Spring Harbor Laboratory) (2023). On theSindex it has a DataRank of 0. It has been cited 5 times.

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Open Access5 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (1 grants)OA: greenTopics (40)IDs (PubMed, OpenAlex)SDGs (2)

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Findable (1/2)

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Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (10)

Jaroslav Žák ORCID,Yujie Shi ORCID,Isaraphorn Pratumchai ORCID,Brandon Dinner ORCID,Wenjian Wang ORCID

Live enrichment

PubMed:36798389 OpenAlex:https://openalex.org/W4319337899

National Institutes of Health

Grant: 5R01AI143884-04

Engineer Immune Cells via Chemoenzymatic Glycan Editing

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repositoryhttps://www.biorxiv.org/content/biorxiv/early/2023/02/07/2023.02.07.527459.full.pdf

publisherhttps://syndication.highwire.org/content/doi/10.1101/2023.02.07.527459

repositoryhttps://doi.org/10.1101/2023.02.07.527459

repositoryhttps://pubmed.ncbi.nlm.nih.gov/36798389

Fields of Study

Immune Cell Function and InteractionCAR-T cell therapy researchEpigenetics and DNA Methylation0301 basic medicine0303 health sciences03 medical and health sciences

Keywords

In vitroCell therapyAdoptive cell transferCellTransient (computer programming)T cellCell biologyCancer researchMedicineStem cellChemistryBiologyCytotoxic T cellImmunologyComputer scienceBiochemistryImmune systemSulfonamidesPyridonesMorpholinesT-LymphocytesBiphenyl CompoundsMelanoma, ExperimentalImmunotherapy, AdoptiveEpigenesis, GeneticMice, Inbred C57BLMiceCell Line, TumorBenzamidesAnimalsHumansEnhancer of Zeste Homolog 2 ProteinHepatocyte Nuclear Factor 1-alphaCell Proliferation

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being