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GSK-3 inhibitor elraglusib enhances tumor-infiltrating immune cell activation in tumor biopsies and synergizes with anti-PD-L1 in a murine model of colorectal cancer

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.02.07.527499Source: DataRank Database

GSK-3 inhibitor elraglusib enhances tumor-infiltrating immune cell activation in tumor biopsies and synergizes with anti-PD-L1 in a murine model of colorectal cancer is a research paper published in bioRxiv (Cold Spring Harbor Laboratory) (2023). On theSindex it has a DataRank of 0. It has been cited 6 times.

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0DataRank · unranked

Scored on demand from live citation data

Open Access6 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (2 grants)OA: greenTopics (35)IDs (PubMed, OpenAlex)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (14)

Anna D. Louie ORCID,Praveen R. Srinivasan ORCID,Christoph Schorl ORCID,Shaolei Lu ORCID,David Silverberg ORCID

Live enrichment

PubMed:36798357 OpenAlex:https://openalex.org/W4319337224

National Institutes of Health

Grant: 1F31CA271636-01

Small-molecule Inhibition of Glycogen Synthase Kinase-3 Sensitizes Colorectal Cancer Cells and Stimulates Immune Cells to Bolster Immune Cell-mediated Tumor Cytotoxicity

National Institutes of Health

Grant: 1S10RR021051-01A2

BD FACSAria Flow Cytometer

greenLicense: cc-by-nd

repositoryhttps://doi.org/10.1101/2023.02.07.527499

publisherhttps://syndication.highwire.org/content/doi/10.1101/2023.02.07.527499

repositoryhttps://pubmed.ncbi.nlm.nih.gov/36798357

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/9934544

Fields of Study

Wnt/β-catenin signaling in development and cancerNF-κB Signaling PathwaysCancer Immunotherapy and Biomarkers0301 basic medicine03 medical and health sciences0302 clinical medicine

Keywords

Immune systemCancer researchImmunotherapyImmune checkpointCytokineT cellTumor-infiltrating lymphocytesCancer immunotherapyBiologyImmunologyMedicineVascular Endothelial Growth Factor AGSK-3Biopsyimmune checkpoint blockadeArticleGranzymesB7-H1 Antigen9-ING-41MiceGlycogen Synthase Kinase 3Disease Models, AnimalLymphocytes, Tumor-InfiltratingCell Line, TumorHumansAnimalselraglusibColorectal NeoplasmsImmune Checkpoint Inhibitors

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being