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PI3K block restores age-dependent neurovascular coupling defects associated with cerebral small vessel disease

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.03.03.531032Source: DataRank Database

PI3K block restores age-dependent neurovascular coupling defects associated with cerebral small vessel disease is a research paper published in bioRxiv (Cold Spring Harbor Laboratory) (2023). On theSindex it has a DataRank of 0. It has been cited 2 times.

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (5 grants)OA: greenTopics (50)IDs (PubMed, OpenAlex)SDGs (1)

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Authors (9)

Evan Yamasaki ORCID,Sher Ali ORCID,Alfredo Sanchez Solano,Cassandre Labelle‐Dumais ORCID,Xiao Gao ORCID

Live enrichment

PubMed:36945616 OpenAlex:https://openalex.org/W4323568593

National Institutes of Health

Grant: 5R01NS096173-03

Genetic and Mechanistic Study of Cerebral Small Vessel Disease

National Institutes of Health

Grant: 5R33NS115132-05

Development and validation of novel models for cerebral small vessel disease and vascular cognitive impairment

National Institutes of Health

Grant: 5P30EY002162-34

P30 - CORE GRANT FOR VISION RESEARCH

National Institutes of Health

Grant: 5P20GM130459-04

Nevada Center of Biomedical Research Excellence in Molecular and Cellular Signal Transduction in the Cardiovascular System

National Institutes of Health

Grant: 3RF1NS110044-01S1

Mechanisms of Functional Vascular Impairment In Genetic Models of Cerebral Small Vessel Disease

greenLicense: CC BY NC ND

repositoryhttps://www.biorxiv.org/content/biorxiv/early/2023/03/06/2023.03.03.531032.full.pdf

publisherhttps://syndication.highwire.org/content/doi/10.1101/2023.03.03.531032

repositoryhttps://doi.org/10.1101/2023.03.03.531032

repositoryhttps://pubmed.ncbi.nlm.nih.gov/36945616

Fields of Study

Mitochondrial Function and PathologyBarrier Structure and Function StudiesCerebrovascular and genetic disorders03 medical and health sciences0302 clinical medicine

Keywords

ArteriolePI3K/AKT/mTOR pathwayVasodilationNeuroscienceCerebral blood flowPhosphatidylinositolCerebral circulationCell biologyBiologyChemistryInternal medicineEndocrinologyMedicineMicrocirculationSignal transduction570AgingCerebrovascularextracellular matrixCOL4A1610HyperemiaNeurodegenerativeMicePhosphatidylinositol 3-KinasesVascular Cognitive Impairment/DementiaAcquired Cognitive Impairment2.1 Biological and endogenous factorsAnimalsAlzheimer's Disease Related Dementias (ADRD)Biomedical and Clinical Sciencescerebral small vessel diseaseNeurosciencesAlzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD)Endothelial CellsBiological SciencesBrain DisordersKir2.1 channelsCerebral Small Vessel DiseasesNeurologicalNeurovascular CouplingDementiaBiochemistry and Cell Biologyfunctional hyperemiaPhosphatidylinositol 3-Kinase

Sustainable Development Goals

SDG 0: Good health and well-being