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Tyrosinase-induced neuromelanin accumulation triggers rapid dysregulation and degeneration of the mouse locus coeruleus

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.03.07.530845Source: DataRank Database

Tyrosinase-induced neuromelanin accumulation triggers rapid dysregulation and degeneration of the mouse locus coeruleus is a research paper published in bioRxiv (Cold Spring Harbor Laboratory) (2023). On theSindex it has a DataRank of 0. It has been cited 18 times.

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Open Access18 citations

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Enrichment:Funding (22 grants)OA: greenTopics (26)IDs (PubMed, OpenAlex)SDGs (1)

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Authors (15)

Bernard Mulvey ORCID,Harris E. Blankenship ORCID,L. Cameron Liles,Amanda L. Sharpe ORCID,Jean-Francoise Pare

Live enrichment

PubMed:36945637 OpenAlex:https://openalex.org/W4323827196

National Institute of Aging

Grant: AG079199

National Institute of Aging

Grant: AG061175

National Institute of Aging

Grant: AG085933

National Institute of Aging

Grant: AG079620

National Institute of Aging

Grant: AG081046

National Institute of Neurological Disease and Stroke

Grant: NS129168

National Institute of Neurological Disease and Stroke

Grant: NS135830

National Institute of Mental Health

Grant: MH015330

Emory National Primate Research Center

Grant: OD011132

National Institute of Environmental Health Sciences

Grant: ES12870

Georgia Clinical and Translational Science Alliance

Grant: UL1TR002378

National Institutes of Health

Grant: 5T32ES012870-20

Graduate and Postdoctoral Training in Environmental Health Science and Toxicology

National Institutes of Health

Grant: 1RF1AG061175-01

Mechanisms underlying selective vulnerability of locus coeruleus neurons in Alzheimer's disease

National Institutes of Health

Grant: 5UL1TR002378-09

Georgia Clinical & Translational Science Alliance (Georgia CTSA)

National Institutes of Health

Grant: 1F99NS129168-01

Investigating Neuromelanin-Mediated Locus Coeruleus Neurodegeneration in a Novel Mouse Model of Parkinson's Disease

National Institutes of Health

Grant: 3RF1AG079199-01S1

Contribution of neuromelanin to selective vulnerability of locus coeruleus neurons in Alzheimer's disease

NIA NIH HHS

Grant: R01 AG079199

NIH HHS

Grant: P51 OD011132

NIEHS NIH HHS

Grant: T32 ES012870

NIA NIH HHS

Grant: RF1 AG061175

NINDS NIH HHS

Grant: F99 NS129168

NIA NIH HHS

Grant: RF1 AG079199

greenLicense: cc-by-nc-nd

repositoryhttps://www.biorxiv.org/content/biorxiv/early/2023/03/10/2023.03.07.530845.full.pdf

publisherhttps://syndication.highwire.org/content/doi/10.1101/2023.03.07.530845

repositoryhttps://doi.org/10.1101/2023.03.07.530845

repositoryhttps://pubmed.ncbi.nlm.nih.gov/36945637

Fields of Study

melanin and skin pigmentationNeuroinflammation and Neurodegeneration MechanismsBiochemical Analysis and Sensing Techniques03 medical and health sciences0302 clinical medicine

Keywords

NeuromelaninLocus coeruleusNeurodegenerationMelaninNeuroscienceCell biologyProgrammed cell deathDegeneration (medical)BiologyChemistrySubstantia nigraInternal medicinePathologyCentral nervous systemMedicineDiseaseBiochemistryDopaminergicDopamineApoptosisArticle

Sustainable Development Goals

SDG 0: Good health and well-being