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DHODH inhibition enhances the efficacy of immune checkpoint blockade by increasing cancer cell antigen presentation

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.04.03.535399Source: DataRank Database

DHODH inhibition enhances the efficacy of immune checkpoint blockade by increasing cancer cell antigen presentation is a research paper published in bioRxiv (Cold Spring Harbor Laboratory) (2023). On theSindex it has a DataRank of 0. It has been cited 4 times.

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Open Access4 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (11 grants)OA: greenTopics (48)IDs (PubMed, OpenAlex)SDGs (1)

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Findable (1/2)

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Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (16)

Surendra K. Shukla ORCID,Ravi Thakur ORCID,Sai Sundeep Kollala ORCID,Dezhen Wang ORCID,Nina V. Chaika ORCID

Live enrichment

PubMed:37066260 OpenAlex:https://openalex.org/W4362603258

National Institutes of Health

Grant: 1R21CA251151-01

PROTACs for pancreatic cancer therapy

National Institutes of Health

Grant: 1R01CA270234-01

Molecular Basis of ME2-mediated Tumor Suppression in Pancreatic Cancer

National Institutes of Health

Grant: 1R35GM126908-01

RNA polymerase II elongation control

National Institutes of Health

Grant: 2R01CA163649-06A1

Targeting MUC1-Mediated Tumor-Stromal Metabolic Cross-Talk in Pancreatic Cancer

National Institutes of Health

Grant: 5F30CA265277-04

Targeting pyrimidine biosynthesis in pancreatic ductal adenocarcinoma

National Institutes of Health

Grant: 1U54CA274329-01

Pancreatic Cancer ARTNet Center

NIGMS NIH HHS

Grant: R35 GM126908

NCI NIH HHS

Grant: R21 CA251151

NCI NIH HHS

Grant: U54 CA274329

NCI NIH HHS

Grant: R01 CA163649

NCI NIH HHS

Grant: F30 CA265277

Influential Citations

Citation Trend

2024

2025

greenLicense: cc-by

repositoryhttps://www.biorxiv.org/content/biorxiv/early/2023/04/05/2023.04.03.535399.full.pdf

GREENhttps://doi.org/10.7554/elife.87292

repositoryhttps://www.biorxiv.org/content/biorxiv/early/2023/04/05/2023.04.03.535399.full.pdf

publisherhttps://syndication.highwire.org/content/doi/10.1101/2023.04.03.535399

repositoryhttps://doi.org/10.1101/2023.04.03.535399

Fields of Study

Biochemical and Molecular ResearchCancer, Hypoxia, and MetabolismRNA modifications and cancerMedicineBiology03 medical and health sciences0302 clinical medicine

Keywords

BlockadeImmune checkpointAntigen presentationAntigenImmune systemPresentation (obstetrics)Cancer researchCancerT cellMedicineImmunotherapyImmunologyReceptorInternal medicineOxidoreductases Acting on CH-CH Group DonorsQH301-705.5ScienceDihydroorotate DehydrogenaseMelanoma, ExperimentalQuinaldinesArticleP-TEFbMiceCell Line, TumorQuinoxalinesMHC-IAnimalsHumansBiology (General)Enzyme InhibitorsImmune Checkpoint InhibitorsCancer Biologypyrimidine nucleotideQBiphenyl CompoundsRDHODHBrequinarMice, Inbred C57BLMHC class IPyrimidine biosynthesis

Sustainable Development Goals

SDG 0: Good health and well-being