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Early Alzheimer’s disease pathology in human cortex is associated with a transient phase of distinct cell states

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.06.03.543569Source: DataRank Database

Early Alzheimer’s disease pathology in human cortex is associated with a transient phase of distinct cell states is a dataset published in bioRxiv (Cold Spring Harbor Laboratory) (2023). On theSindex it has a DataRank of 0.447, placing it in the top 42.1% of the data-sharing corpus. It has been cited 9 times, with 6 citing works in its 1-hop citation network.

Top 42%percentile

0.447DataRank

Ranks in the top 42% for downstream scientific impact

Data paper Open Access9 citations · 6 citing works in its network

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DataRank reads this dataset's downstream impact straight off the citation graph — no black box, no proprietary weighting. How is this computed?

›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (7 grants)OA: greenTopics (19)IDs (PubMed, OpenAlex)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (1/3)

Dataset classification

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DataRank Breakdown

Base Score 77%Citation Network 23%

Base Score Contribution

0.345

From this paper's citation signal

Citation Network Contribution

0.101

From 5 citing papers with measurable signal

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Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 6 citers.

A pharmacological toolkit for human microglia identifies Topoisomerase I inhibitors as immunomodulators for Alzheimer’s disease
bioRxiv (Cold Spring Harbor Laboratory)202416 citations79 referencesContributes 0.036
Oligodendrocytes and neurons contribute to amyloid-β deposition in Alzheimer’s disease
bioRxiv (Cold Spring Harbor Laboratory)20233 citations40 referencesContributes 0.035
Layer 1 neocortex: Gating and integrating multidimensional signals
Neuron202337 citations183 referencesContributes 0.020
Comparative mapping of single-cell transcriptomic landscapes in neurodegenerative diseases
bioRxiv (Cold Spring Harbor Laboratory)20244 citations97 referencesContributes 0.017
Single-cell technology for drug discovery and development
Frontiers in Drug Discovery20247 citations171 referencesContributes 0.012

Authors (19)

Tushar Kamath ORCID,Naeem Nadaf ORCID,S.J. Burris ORCID,Brenda L. Rooney ORCID,Antti Junkkari ORCID

Live enrichment

PubMed:37333365 OpenAlex:https://openalex.org/W4379515600

Research Council of Finland

Grant: 328287

Regulation of neuroinflammation in Alzheimer's disease by non-coding RNAs

Research Council of Finland

Grant: 339763

Clinical and experimental study on human neuronal circuitry and cellular heterogeneity impacted by early Alzheimers disease -related pathology in iNPH patients (CLEAR)

National Institutes of Health

Grant: 3T32GM007753-41S1

Medical Scientist Training Program

Research Council of Finland

Grant: 334801

Multicellular organoids: modeling, mechanisms and therapy development for C9ORF72-associated neurodegeneration

Research Council of Finland

Grant: 338182

Mechanisms of microglia-specific genetic variants associated with Alzheimers disease

European Commission

Grant: 101043584

Window to the brain: a game changer in the discovery of human neuronal circuitry, cellular heterogenicity and biomarker profile indicative of early Alzheimer's disease -related pathology

National Institutes of Health

Grant: 5F30AG069446-02

Characterizing the landscape of cell-type specific changes associated with Alzheimer's disease before death with single-cell genomics

greenLicense: cc-by-nd

repositoryhttps://www.biorxiv.org/content/biorxiv/early/2023/06/05/2023.06.03.543569.full.pdf

repositoryhttp://dx.doi.org/10.1101/2023.06.03.543569

repositoryhttps://pubmed.ncbi.nlm.nih.gov/37333365

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/10274680

Fields of Study

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatmentsTryptophan and brain disorders03 medical and health sciences0302 clinical medicine

Keywords

NeuroscienceNeuroinflammationMicrogliaPathologicalAlzheimer's diseaseDiseaseCortex (anatomy)PathologyPathogenesisBiologyMedicineInflammationImmunologyArticle