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Cocaine Regulates Antiretroviral Therapy CNS Access Through Pregnane-X Receptor-Mediated Drug Transporter and Metabolizing Enzyme Modulation at the Blood Brain Barrier

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.07.28.551042Source: DataRank Database

Cocaine Regulates Antiretroviral Therapy CNS Access Through Pregnane-X Receptor-Mediated Drug Transporter and Metabolizing Enzyme Modulation at the Blood Brain Barrier is a research paper published in bioRxiv (Cold Spring Harbor Laboratory) (2023). On theSindex it has a DataRank of 0. It has been cited 1 time.

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Enrichment:Funding (18 grants)OA: greenTopics (30)IDs (PubMed, OpenAlex)SDGs (1)

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Authors (9)

Stephen Knerler,A C Price ORCID,Rodnie Colón Ortiz ORCID,Alicia Mercado ORCID,Hannah Wilkins ORCID

Live enrichment

PubMed:37546800 OpenAlex:https://openalex.org/W4385374803

National Institutes of Health

Grant: 3P30AI094189-13S3

The Johns Hopkins Center for AIDS Research (JHU CFAR)

National Institutes of Health

Grant: 5R00DA044838-05

COCAINE USE AND HIV ANTIRETROVIRAL THERAPY EFFICACY IN THE CNS

National Institutes of Health

Grant: 2P30MH075673-11A1

JHU NIMH Center for Novel Therapeutics for HIV-associated Cognitive Disorders

National Institutes of Health

Grant: 3R01GM103853-07A1S1

Cellular Signaling in Drug Induced Toxicity

National Institutes of Health

Grant: 5U01DA058527-03

Elucidating single cell changes in neurogenic brain regions during HIV and cannabinoid exposure

National Institutes of Health

Grant: 3T32GM144272-02S1

Biochemistry, Cellular and Molecular Biology Program: JHU BioGREAT (Biomedical Graduate REsiliency & Adaptability Training)

National Institutes of Health

Grant: 5R25GM109441-05

HopkinsPREP: Research, Community, Professional Training and Personal Growth

National Institutes of Health

Grant: 3R01AG064908-03S1

Drug Phosphorylation and Aging

National Institutes of Health

Grant: 7R01DA052859-05

Cannabidiol and Macrophage Chronic Inflammation in a Virally Suppressed Rhesus Macaque Model

NIMH NIH HHS

Grant: P30 MH075673

NIAID NIH HHS

Grant: P30 AI094189

NIA NIH HHS

Grant: R01 AG064908

NIGMS NIH HHS

Grant: R01 GM103853

NIDA NIH HHS

Grant: R00 DA044838

NIGMS NIH HHS

Grant: T32 GM144272

NIDA NIH HHS

Grant: R01 DA052859

NIGMS NIH HHS

Grant: R25 GM109441

NIDA NIH HHS

Grant: U01 DA058527

greenLicense: cc-by-nc-nd

repositoryhttps://www.biorxiv.org/content/biorxiv/early/2023/07/29/2023.07.28.551042.full.pdf

GREENhttps://fluidsbarrierscns.biomedcentral.com/counter/pdf/10.1186/s12987-023-00507-3

repositoryhttps://www.biorxiv.org/content/biorxiv/early/2023/07/29/2023.07.28.551042.full.pdf

publisherhttps://syndication.highwire.org/content/doi/10.1101/2023.07.28.551042

repositoryhttps://doi.org/10.1101/2023.07.28.551042

Fields of Study

Drug Transport and Resistance MechanismsHIV/AIDS drug development and treatmentHIV Research and TreatmentBiologyMedicineChemistry03 medical and health sciences0305 other medical science

Keywords

Pregnane X receptorBlood–brain barrierPharmacologyDrugTight junctionExtravasationDrug deliveryChemistryMedicineNuclear receptorCentral nervous systemInternal medicineImmunologyBiochemistryArticleAntiretroviral therapyBlood brain barrierCocaineDrug MetabolismDrug TransportHIVPregnane-X Receptor

Sustainable Development Goals

SDG 0: Good health and well-being