Pilot corpus: NIH-funded biomedical datasets. Any DOI can be scored on demand — network effects sharpen as coverage grows.

Alzheimer’s disease linked Aβ42 exerts product feedback inhibition on γ-secretase impairing downstream cell signaling

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.08.02.551596Source: DataRank Database

Alzheimer’s disease linked Aβ42 exerts product feedback inhibition on γ-secretase impairing downstream cell signaling is a research paper published in bioRxiv (Cold Spring Harbor Laboratory) (2023). On theSindex it has a DataRank of 0. It has been cited 5 times.

N/A

0DataRank · unranked

Scored on demand from live citation data

Open Access5 citations

Download PDF

Cite:

DataRank reads this dataset's downstream impact straight off the citation graph — no black box, no proprietary weighting. How is this computed?

›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (8 grants)OA: greenTopics (71)IDs (PubMed, OpenAlex)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

FAIR checklist signals are shown for context only and do not affect DataRank scoring.

Run a calibrated FAIR evaluation for this paper →

We only score data papers we can read in full — never from an abstract alone.

Authors (16)

Utpal Das ORCID,Sam Lismont ORCID,Thomas Enzlein ORCID,Masato Maesako ORCID,Mei CQ Houser ORCID

Live enrichment

PubMed:37577527 OpenAlex:https://openalex.org/W4385551829

National Institutes of Health

Grant: 5R01AG055523-02

Treating with Gamma-Secretase Modulators to Prevent Neurodegeneration in Mouse Models of Down Syndrome and Alzheimer Disease

National Institutes of Health

Grant: 2P01AG015379-11

Presenilin Biology and the Mechanism of Alzheimers Disease

National Institutes of Health

Grant: 5R01AG044486-04

Role of PS1 in neurodegeneration

NIA NIH HHS

Grant: R01 AG055523

NIA NIH HHS

Grant: P01 AG015379

NIA NIH HHS

Grant: RF1 AG044486

NIA NIH HHS

Grant: R01 AG044486

NIA NIH HHS

Grant: R01 AG070154

greenLicense: cc-by-nc

repositoryhttps://www.biorxiv.org/content/biorxiv/early/2023/08/02/2023.08.02.551596.full.pdf

GREENhttps://www.biorxiv.org/content/biorxiv/early/2023/08/02/2023.08.02.551596.full.pdf

repositoryhttps://www.biorxiv.org/content/biorxiv/early/2023/08/02/2023.08.02.551596.full.pdf

publisherhttps://syndication.highwire.org/content/doi/10.1101/2023.08.02.551596

repositoryhttps://doi.org/10.1101/2023.08.02.551596

Fields of Study

Alzheimer's disease research and treatmentsNuclear Receptors and SignalingComputational Drug Discovery MethodsBiologyMedicine0302 clinical medicine03 medical and health sciences

Keywords

Downstream (manufacturing)Amyloid precursor protein secretaseDiseaseNeuroscienceCell biologySignal transductionProduct (mathematics)CellChemistryAlzheimer's diseaseAmyloid precursor proteinBiologyMedicineInternal medicineBusinessBiochemistryLife Sciences & Biomedicine - Other TopicsMECHANISMMouseAmyloid toxicity0601 Biochemistry and Cell BiologyMiceGamma-secretase inhibitionpresenilinPEPTIDEratDOWN-SYNDROMEBiology (General)gamma-secretaseNeuronsFeedback, PhysiologicalHYPOTHESISQRMOUSE MODELChemical biologyAlzheimer’s diseaseLife Sciences & BiomedicineHuman570QH301-705.5PhysiologicalScience610ArticleFeedbackCell LineBiochemistry and Chemical BiologyAlzheimer DiseaseHumansAnimalsA-BETAScience & Technology42 Health sciencesAmyloid beta-PeptidesMUTATIONS31 Biological sciencesAmyloid beta32 Biomedical and clinical sciencesDYSFUNCTIONPeptide FragmentsAlzheimers diseaseAmyloid Precursor Protein SecretasesAPP

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being