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Gas tunnel engineering of prolyl hydroxylase reprograms hypoxia signaling in cells

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.08.07.552357Source: DataRank Database

Gas tunnel engineering of prolyl hydroxylase reprograms hypoxia signaling in cells is a research paper published in bioRxiv (Cold Spring Harbor Laboratory) (2023). On theSindex it has a DataRank of 0.

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (4 grants)OA: greenTopics (31)IDs (PubMed, OpenAlex)SDGs (1)

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Authors (6)

Haiping Ouyang,Joseph A. G. da Costa,Anoop R. Damodaran ORCID,Yue Chen ORCID,Ambika Bhagi‐Damodaran ORCID

Live enrichment

PubMed:37609209 OpenAlex:https://openalex.org/W4385661009

National Science Foundation

Grant: 1753154

CAREER: Functional Dissection of Ubiquitination Signaling by Quantitative Chemical Proteomics

National Institutes of Health

Grant: 1R35GM124896-01

Functional Dissection of Metabolic-Sensing Proline Hydroxylation Pathways

NIGMS NIH HHS

Grant: R35 GM124896

NIGMS NIH HHS

Grant: R35 GM138277

greenLicense: cc-by-nd

repositoryhttps://www.biorxiv.org/content/biorxiv/early/2023/09/12/2023.08.07.552357.full.pdf

publisherhttps://syndication.highwire.org/content/doi/10.1101/2023.08.07.552357

repositoryhttps://doi.org/10.1101/2023.08.07.552357

repositoryhttps://pubmed.ncbi.nlm.nih.gov/37609209

Fields of Study

Cancer, Hypoxia, and MetabolismMitochondrial Function and PathologyHemoglobin structure and function0301 basic medicine03 medical and health sciences

Keywords

Protein engineeringHEK 293 cellsMutantCell biologyTransfectionChemistryHydroxylationNanotechnologyBiologyBiochemistryEnzymeMaterials scienceGeneOxygenHEK293 CellsProcollagen-Proline DioxygenaseHumansArticleCell HypoxiaSignal TransductionHypoxia-Inducible Factor-Proline Dioxygenasescellular signalinggas tunnelsnon-heme ironoxygen sensingprotein design

Sustainable Development Goals

SDG 0: Clean water and sanitation