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Discovery of 2-amide-3-methylester thiophenes that target SARS-CoV-2 Mac1 and repress coronavirus replication, validating Mac1 as an anti-viral target

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.08.28.555062Source: DataRank Database

Discovery of 2-amide-3-methylester thiophenes that target SARS-CoV-2 Mac1 and repress coronavirus replication, validating Mac1 as an anti-viral target is a research paper published in bioRxiv (Cold Spring Harbor Laboratory) (2023). On theSindex it has a DataRank of 0. It has been cited 6 times.

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Open Access6 citations

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Enrichment:Funding (8 grants)OA: greenTopics (32)IDs (PubMed, OpenAlex)Annotations (1)SDGs (2)

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Findable (1/2)

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Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (12)

Tomi A. O. Parviainen ORCID,Jessica J. Pfannenstiel ORCID,Men Thi Hoai Duong ORCID,Daniel Cluff ORCID,Sven T. Sowa ORCID

Live enrichment

PubMed:38234730 OpenAlex:https://openalex.org/W4386293964

National Institutes of Health

Grant: 5P20GM113117-03

Chemical Biology of Infectious Disease

National Institutes of Health

Grant: 5UL1TR002366-04

Frontiers: University of Kansas Clinical and Translational Science Institute

National Institutes of Health

Grant: 1R35GM138029-01

Determining mechanisms of innate immune modulation by ADP-ribosylation

National Institutes of Health

Grant: 5P30GM110761-04

Protein Structure and Function

NIGMS NIH HHS

Grant: P20 GM113117

NIGMS NIH HHS

Grant: P30 GM110761

NIGMS NIH HHS

Grant: R35 GM138029

NCATS NIH HHS

Grant: UL1 TR002366

greenLicense: cc-by

repositoryhttps://www.biorxiv.org/content/biorxiv/early/2023/08/29/2023.08.28.555062.full.pdf

publisherhttps://syndication.highwire.org/content/doi/10.1101/2023.08.28.555062

repositoryhttps://doi.org/10.1101/2023.08.28.555062

repositoryhttps://pubmed.ncbi.nlm.nih.gov/38234730

Fields of Study

PARP inhibition in cancer therapyRNA and protein synthesis mechanismsSARS-CoV-2 and COVID-19 Research0301 basic medicine03 medical and health sciences

Keywords

Viral replicationCoronavirusSmall moleculeSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Computational biologyBiologyDrug discoveryVirusVirologyChemistryCoronavirus disease 2019 (COVID-19)Cell biologyGeneticsBiochemistryMedicineMurine hepatitis virusSARS-CoV-2ThiophenesVirus ReplicationCrystallography, X-RayAntiviral AgentsArticleCOVID-19 Drug TreatmentMiceStructure-Activity RelationshipHumansAnimals

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being

Discovery of 2-amide-3-methylester thiophenes that target SARS-CoV-2 Mac1 and repress coronavirus replication, validating Mac1 as an anti-viral target

FAIR Checklist

Authors (12)

Funding (8 grants)

Open Access

Topics

Annotations (Europe PMC)