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GWAS meta-analysis of psoriasis identifies new susceptibility alleles impacting disease mechanisms and therapeutic targets

medRxiv(2023)10.1101/2023.10.04.23296543Source: DataRank Database

GWAS meta-analysis of psoriasis identifies new susceptibility alleles impacting disease mechanisms and therapeutic targets is a research paper published in medRxiv (2023). On theSindex it has a DataRank of 0.872. It has been cited 31 times, with 22 citing works in its 1-hop citation network.

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0.872DataRank · unranked

Scored on demand from live citation data

Open Access31 citations · 22 citing works in its network

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (28 grants)OA: greenTopics (40)IDs (PubMed, OpenAlex)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 60%Citation Network 40%

Base Score Contribution

0.520

From this paper's citation signal

Citation Network Contribution

0.352

From 13 citing papers with measurable signal

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Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 22 citers.

Exposure to Air Pollution, Genetic Susceptibility, and Psoriasis Risk in the UK
JAMA Network Open202435 citations44 referencesContributes 0.081
Genome-Wide Differential Transcription of Long Noncoding RNAs in Psoriatic Skin
International Journal of Molecular Sciences202314 citations53 referencesContributes 0.051
scTWAS Atlas: an integrative knowledgebase of single-cell transcriptome-wide association studies
Nucleic Acids Research20248 citations48 referencesContributes 0.046
RNA Sequencing Reveals the Long Non‐Coding RNA Signature in Psoriasis Keratinocytes and Identifies CYDAER as a Long Non‐Coding RNA Regulating Epidermal Differentiation
Experimental Dermatology20258 citations49 referencesContributes 0.045
Evidence for the gut‐skin axis: Common genetic structures in inflammatory bowel disease and psoriasis
Skin Research and Technology202418 citations70 referencesContributes 0.042

Authors (86)

Philip E. Stuart ORCID,John Bowes ORCID,David Ellinghaus ORCID,Joanne Nititham ORCID,Jake Saklatvala ORCID

Live enrichment

PubMed:37873414 OpenAlex:https://openalex.org/W4387358894

National Institutes of Health

Grant: 5R01AR050511-10

Identification of Psoriatic Arthritis Genes

National Institutes of Health

Grant: 1R01AR054966-01

Combined analysis of gene expression and DNA variation in psoriasis

National Institutes of Health

Grant: 5R01AR065174-02

Identification of Causal Variants in Psoriasis

National Institutes of Health

Grant: 5R01AR065183-02

Functional Genomics of Psoriasis

National Institutes of Health

Grant: 5U01AI119125-04

MHC and KIR Region Genomics in Psoriasis

UK Research and Innovation

Grant: MR/S003126/1

Improving diagnosis and treatment for the quantified patient

National Institutes of Health

Grant: 5K01AR072129-02

Integrative Biology Approach to Identify and Characterize Roles of lncRNAs Associated with Psoriasis Pathology

National Institutes of Health

Grant: 5K08AR078251-04

Mechanisms of sex discrepancy in autoimmune disease: Regulation of the female-biased VGLL3 immune pathway

European Commission

Grant: 821511

Biomarkers in Atopic Dermatitis and Psoriasis

National Institutes of Health

Grant: 5R01ES033634-02

Functional genomics of GxE in cardiovascular disease: BPA, phthalates and their interactions with gene regulation

National Institutes of Health

Grant: 5R01AR063611-04

Genetic and Genomic Dissection of Psoriatic Arthritis

National Institutes of Health

Grant: 5UC2AR081033-04

Immunogenomics and Systems Biology Core

National Institutes of Health

Grant: 2R35GM138121-06

Resolving Methodological Challenges in Genomics Research: Causality, Risk Prediction, and Reproducibility

National Institutes of Health

Grant: 5R01AR042742-07

LINKAGE ANALYSIS OF FAMILIAL PSORIASIS

National Institutes of Health

Grant: 5P30AR075043-04

University of Michigan Skin Biology and Diseases Resource-based Center

NIEHS NIH HHS

Grant: R01 ES033634

NIAID NIH HHS

Grant: U01 AI119125

NIAMS NIH HHS

Grant: K08 AR078251

NIAMS NIH HHS

Grant: P30 AR075043

NIAMS NIH HHS

Grant: K01 AR072129

NIAMS NIH HHS

Grant: R01 AR042742

NIAMS NIH HHS

Grant: R01 AR054966

NIAMS NIH HHS

Grant: R01 AR050511

NIAMS NIH HHS

Grant: R01 AR065174

NIGMS NIH HHS

Grant: R35 GM138121

NIAMS NIH HHS

Grant: UC2 AR081033

NIAMS NIH HHS

Grant: R01 AR065183

NIAMS NIH HHS

Grant: R01 AR063611

Influential Citations

Citation Trend

2023

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2025

2026

greenLicense: cc-by-nc-nd

repositoryhttps://www.medrxiv.org/content/medrxiv/early/2023/10/05/2023.10.04.23296543.full.pdf

GREENhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10593001

repositoryhttps://www.medrxiv.org/content/medrxiv/early/2023/10/05/2023.10.04.23296543.full.pdf

publisherhttps://syndication.highwire.org/content/doi/10.1101/2023.10.04.23296543

repositoryhttps://doi.org/10.1101/2023.10.04.23296543

Fields of Study

Psoriasis: Treatment and PathogenesisAsthma and respiratory diseasesCytokine Signaling Pathways and InteractionsMedicineBiology0301 basic medicine03 medical and health sciences

Keywords

PsoriasisGenome-wide association studyEpigeneticsBiologyDiseaseTranscriptomeGeneticsGenetic predispositionAlleleSingle-nucleotide polymorphismImmunologyMedicineGenotypeGeneGene expressionInternal medicineScienceInterleukin-17QSingle NucleotidePolymorphism, Single NucleotideReceptors, Aryl Hydrocarbon/geneticsArticlePsoriasis/geneticsAryl HydrocarbonReceptors, Interleukin-17/geneticsReceptorsSkin/metabolismHumansGenetic Predisposition to DiseasePolymorphismAllelesSkin

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being