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IFIH1 (MDA5) is required for innate immune detection of intron-containing RNA expressed from the HIV-1 provirus

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.11.17.567619Source: DataRank Database

IFIH1 (MDA5) is required for innate immune detection of intron-containing RNA expressed from the HIV-1 provirus is a research paper published in bioRxiv (Cold Spring Harbor Laboratory) (2023). On theSindex it has a DataRank of 0. It has been cited 1 time.

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Enrichment:Funding (2 grants)OA: greenTopics (35)IDs (PubMed, OpenAlex)SDGs (1)

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Authors (6)

Karthika Nagalekshmi ORCID,Sean Matthew McCauley ORCID,Claudia Carbone ORCID,Özkan Aydemir ORCID,Jeremy Luban ORCID

Live enrichment

PubMed:38014177 OpenAlex:https://openalex.org/W4388792931

National Institutes of Health

Grant: 1U54AI170856-01

CHEETAH Center for the Structural Biology of HIV Infection, Restriction, and Viral Dynamics

National Institutes of Health

Grant: 5R37AI147868-05

The HUSH complex in HIV-1 latency

greenLicense: cc-by-nc-nd

repositoryhttps://www.biorxiv.org/content/biorxiv/early/2023/12/12/2023.11.17.567619.full.pdf

GREENhttps://www.biorxiv.org/content/biorxiv/early/2023/12/12/2023.11.17.567619.full.pdf

repositoryhttps://www.biorxiv.org/content/biorxiv/early/2023/12/12/2023.11.17.567619.full.pdf

publisherhttps://syndication.highwire.org/content/doi/10.1101/2023.11.17.567619

repositoryhttp://dx.doi.org/10.1101/2023.11.17.567619

Fields of Study

interferon and immune responsesHIV Research and TreatmentImmune Cell Function and InteractionBiologyMedicine0301 basic medicine03 medical and health sciences

Keywords

Gene knockdownInnate immune systemBiologyMDA5ProvirusRNAVirologyInterferonImmune systemIntronMolecular biologyRNA interferenceGeneImmunologyGeneticsInterferon-Induced Helicase, IFIH1HIV InfectionsDendritic CellsBiological SciencesKaryopherinsArticleImmunity, InnateIntronsProvirusesHIV-1HumansRNA, ViralAdaptor Proteins, Signal Transducing

Sustainable Development Goals

SDG 0: Good health and well-being