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Proinflammatory Cytokines Suppress Nonsense-Mediated RNA Decay to Impair Regulated Transcript Isoform Processing in Pancreatic β-Cells

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.12.20.572623Source: DataRank Database

Proinflammatory Cytokines Suppress Nonsense-Mediated RNA Decay to Impair Regulated Transcript Isoform Processing in Pancreatic β-Cells is a research paper published in bioRxiv (Cold Spring Harbor Laboratory) (2023). On theSindex it has a DataRank of 0.

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Enrichment:Funding (5 grants)OA: greenTopics (38)IDs (PubMed, OpenAlex)SDGs (2)

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Authors (7)

Piero Marchetti ORCID,Lorenzo Piemonti ORCID,Jens Høiriis Nielsen ORCID,Bo T. Porse ORCID,Thomas Mandrup‐Poulsen ORCID

Live enrichment

PubMed:38187722 OpenAlex:https://openalex.org/W4390062308

National Institutes of Health

Grant: 5R01DK135268-02

Control of insulin secretion by mitochondrial fusion

Canadian Institutes of Health Research

Grant: unidentified

unidentified

UK Research and Innovation

Grant: MR/R022259/1

Genetic and nutritional control of pancreatic beta cell identity.

Wellcome Trust

Grant: 212625

Understanding pancreatic beta cell connectivity

European Commission

Grant: 115881

Assessing risk and progression of prediabetes and type 2 diabetes to enable disease modification - Sofia ref.: 115881

greenLicense: cc-by

repositoryhttps://www.biorxiv.org/content/biorxiv/early/2023/12/21/2023.12.20.572623.full.pdf

publisherhttps://syndication.highwire.org/content/doi/10.1101/2023.12.20.572623

repositoryhttps://doi.org/10.1101/2023.12.20.572623

repositoryhttps://pubmed.ncbi.nlm.nih.gov/38187722

Fields of Study

Pancreatic function and diabetesDiabetes and associated disordersRNA modifications and cancer

Keywords

Proinflammatory cytokineGene isoformNonsense-mediated decayNonsenseCell biologyRNAMessenger RNABiologyChemistryImmunologyGeneticsGeneInflammationRNA splicing570insulin secretionInsulins610β-cellsRNA-Binding ProteinsRC648-665RNA decayDiseases of the endocrine glands. Clinical endocrinologyArticleRatsNonsense Mediated mRNA DecayEndocrinologyRNA processingDiabetes Mellitus, Type 2Insulin-Secreting CellsHumansAnimalsCytokinesProtein Isoformstranscript

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being