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Diroximel fumarate acts through Nrf2 to attenuate methylglyoxal-induced nociception in mice and decreases ISR activation in DRG neurons

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.12.22.572877Source: DataRank Database

Diroximel fumarate acts through Nrf2 to attenuate methylglyoxal-induced nociception in mice and decreases ISR activation in DRG neurons is a research paper published in bioRxiv (Cold Spring Harbor Laboratory) (2023). On theSindex it has a DataRank of 0.

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Enrichment:Funding (5 grants)OA: greenTopics (27)IDs (PubMed, OpenAlex)SDGs (2)

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Open Access

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Authors (9)

Marisol Mancilla Moreno ORCID,Jiahe Li ORCID,Lucy He,Danielle Royer ORCID,Jennifer Zhang ORCID

Live enrichment

PubMed:38187575 OpenAlex:https://openalex.org/W4390154334

Natural Sciences and Engineering Research Council of Canada

Grant: unidentified

unidentified

National Institutes of Health

Grant: 1RF1NS113840-01

Nrf2 Activation for Addiction-Free Treatment of Neuropathic Pain

National Institutes of Health

Grant: 1R01DK134893-01

Targeting methylglyoxal-induced diabetic neuropathic pain through the integrated stress response

NIDDK NIH HHS

Grant: R01 DK134893

NINDS NIH HHS

Grant: RF1 NS113840

greenLicense: cc-by-nc-nd

repositoryhttps://www.biorxiv.org/content/biorxiv/early/2023/12/23/2023.12.22.572877.full.pdf

publisherhttps://syndication.highwire.org/content/doi/10.1101/2023.12.22.572877

repositoryhttps://doi.org/10.1101/2023.12.22.572877

repositoryhttps://pubmed.ncbi.nlm.nih.gov/38187575

Fields of Study

Pain Mechanisms and TreatmentsExercise and Physiological ResponsesFibromyalgia and Chronic Fatigue Syndrome Research0301 basic medicine03 medical and health sciences

Keywords

MethylglyoxalDorsal root ganglionNociceptionNeuropathic painPharmacologyHyperalgesiaChemistryMetaboliteNeuriteKnockout mouseMedicineIn vitroBiochemistryDorsumReceptorAnatomyArticleNeurosciencediroximel fumarateintegrated stress responsenrf2pain

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being