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The IFIH1-A946T risk variant promotes diabetes in a sex-dependent manner

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.01.20.576482Source: DataRank Database

The IFIH1-A946T risk variant promotes diabetes in a sex-dependent manner is a research paper published in bioRxiv (Cold Spring Harbor Laboratory) (2024). On theSindex it has a DataRank of 0.

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (4 grants)OA: greenTopics (41)IDs (PubMed, OpenAlex)SDGs (2)

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Open Access

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Authors (14)

Pierina Gonzalez-Paredes,Luciana Previato de Almeida,Stanley D. Kosanke,Srinivaas Chetlur,Hannah Budde

Live enrichment

PubMed:38328221 OpenAlex:https://openalex.org/W4391151541

National Institutes of Health

Grant: 1DP3DK097672-01

Defining the functional impact of T1D genes in mouse and man: a unified strategy

National Institutes of Health

Grant: 1S10OD028479-01

5-Laser Cytek Aurora Spectral Flow Cytometer

National Institutes of Health

Grant: 1DP3DK111802-01

An integrated strategy to define the functional and synergistic impact of T1D causal variants

National Institutes of Health

Grant: 3P20GM139763-03S1

Center for Cellular Metabolism Research in Oklahoma

greenLicense: CC BY

repositoryhttps://www.biorxiv.org/content/biorxiv/early/2024/01/23/2024.01.20.576482.full.pdf

publisherhttps://syndication.highwire.org/content/doi/10.1101/2024.01.20.576482

repositoryhttp://dx.doi.org/10.1101/2024.01.20.576482

repositoryhttps://pubmed.ncbi.nlm.nih.gov/38328221

Fields of Study

Diabetes and associated disordersImmune Cell Function and Interactioninterferon and immune responses0301 basic medicine0303 health sciences03 medical and health sciences

Keywords

InsulitisPathogenesisNodSNPImmune systemDiabetes mellitusSingle-nucleotide polymorphismInterferonGeneNOD miceBiologyEndocrinologyInternal medicineMedicineImmunologyBiochemistryGenotypeMDA5Interferon-Induced Helicase, IFIH1diabetesT cellsRC581-607CD8-Positive T-LymphocytesAutoimmune DiseasesDEAD-box RNA HelicasesMiceDiabetes Mellitus, Type 1type I interferonsMice, Inbred NODAnimalsFemaleGenetic Predisposition to DiseaseInterferonsImmunologic diseases. AllergyIFIH1

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being