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Cryo-EM Structures Reveal Tau Filaments from Down Syndrome Adopt Alzheimer’s Disease Fold

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.04.02.587507Source: DataRank Database

Cryo-EM Structures Reveal Tau Filaments from Down Syndrome Adopt Alzheimer’s Disease Fold is a research paper published in bioRxiv (Cold Spring Harbor Laboratory) (2024). On theSindex it has a DataRank of 0.

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Enrichment:Funding (4 grants)OA: greenTopics (78)IDs (PubMed, OpenAlex)Annotations (2)SDGs (2)

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Authors (10)

Eric Tse ORCID,Hyunjun Yang ORCID,Marie Shi,Christoffer D. Caro,Feng Wang ORCID

Live enrichment

PubMed:38617229 OpenAlex:https://openalex.org/W4394065251

National Institutes of Health

Grant: 3RF1NS133651-01S1

Structural characterization of tau conformational heterogeneity in Down syndrome

National Institutes of Health

Grant: 1R13AG013039-01

1995 SUMMER INSTITUTE IN GERIATRIC MEDICINE

National Institutes of Health

Grant: 5P01AG002132-32

Degenerative and Dementing Diseases of Aging

National Institutes of Health

Grant: 3P30AG066519-01S1

The Alzheimer's Disease Research Center at the University of California, Irvine

greenLicense: cc-by-nc-nd

repositoryhttps://www.biorxiv.org/content/biorxiv/early/2024/04/03/2024.04.02.587507.full.pdf

publisherhttps://syndication.highwire.org/content/doi/10.1101/2024.04.02.587507

repositoryhttps://doi.org/10.1101/2024.04.02.587507

repositoryhttps://pubmed.ncbi.nlm.nih.gov/38617229

Fields of Study

Advanced Electron Microscopy Techniques and ApplicationsAlzheimer's disease research and treatmentsMitochondrial Function and Pathology0301 basic medicine0303 health sciences03 medical and health sciences

Keywords

Fold (higher-order function)Alzheimer's diseaseDiseaseNeuroscienceComputer scienceMedicineBiologyPathologyProgramming languageDown Syndrome (mesh)Neurofibrillary Tangles (mesh)MaleAgingDown syndromeCryo–electron microscopyNeurodegenerativeAcquired Cognitive Impairment (rcdc)Aging (rcdc)Brain Disorders (rcdc)1103 Clinical Sciences (for)Dementia (rcdc)2.1 Biological and endogenous factorsIntellectual and Developmental Disabilities (IDD) (rcdc)Male (mesh)3101 Biochemistry and cell biology (for-2020)Neurosciences (rcdc)Neurodegenerative (rcdc)Cryoelectron Microscopy (mesh)Alzheimer Disease (mesh)Humans (mesh)Alzheimer's Disease (rcdc)BrainNeurofibrillary TanglesBiological SciencesMiddle Aged3209 Neurosciences (for-2020)TauopathyProtein conformationNeurologicalFemaleCryo-electron microscopyAlzheimer’s diseaseAdult570Intellectual and Developmental Disabilities (IDD)Clinical Sciences0601 Biochemistry and Cell Biology (for)610tau ProteinsBrain (mesh)Alzheimer DiseaseMiddle Aged (mesh)Acquired Cognitive ImpairmentHumansRC346-42931 Biological Sciences (for-2020)Neurological (hrcs-hc)ResearchCryoelectron MicroscopyNeurosciencesAlzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD)2.1 Biological and endogenous factors (hrcs-rac)1109 Neurosciences (for)Brain DisordersFemale (mesh)Adult (mesh)Down Syndrome (rcdc)DementiaAlzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) (rcdc)Biochemistry and Cell BiologyNeurology. Diseases of the nervous systemtau Proteins (mesh)

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being

Cryo-EM Structures Reveal Tau Filaments from Down Syndrome Adopt Alzheimer’s Disease Fold

FAIR Checklist

Authors (10)

Funding (4 grants)

Open Access

Topics

Annotations (Europe PMC)