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SARS-CoV-2 ORF3a Protein Impairs Syncytiotrophoblast Maturation, Alters ZO-1 Localization, and Shifts Autophagic Pathways in Trophoblast Cells and 3D Organoids

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.09.25.614931Source: DataRank Database

SARS-CoV-2 ORF3a Protein Impairs Syncytiotrophoblast Maturation, Alters ZO-1 Localization, and Shifts Autophagic Pathways in Trophoblast Cells and 3D Organoids is a research paper published in bioRxiv (Cold Spring Harbor Laboratory) (2024). On theSindex it has a DataRank of 0. It has been cited 1 time.

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (16 grants)OA: greenTopics (25)IDs (PubMed, OpenAlex)SDGs (1)

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Authors (10)

Rowan M. Karvas ORCID,Brittany L. Jones ORCID,Eliza McColl,Emily Diveley,Sukanta Jash

Live enrichment

PubMed:39386577 OpenAlex:https://openalex.org/W4402838298

National Institutes of Health

Grant: 3R01HD091218-04S1

Safety, Testing/Transmission, and Outcomes in Pregnancy with COVID-19 (STOP-COVID-19 study)

National Institutes of Health

Grant: 5P20GM121298-02

COBRE for Reproductive Health

National Institutes of Health

Grant: 1R01HD110408-01A1

Targeting proteinopathy/tauopathy and impaired autophagy for mechanistic understanding and therapeutic intervention of preeclampsia

National Institutes of Health

Grant: 1DP2GM137418-01

Resolving epigenetic instability during pluripotent state transitions: a roadmap for exploiting the biomedical potential of dynamic human stem cell states

National Institutes of Health

Grant: 1R01HD113199-01

The Opioid in Pregnancy: Imaging of Oxygenation, Inflammation, and Development in Brain & Placenta Project (OPIOID BPP)

National Institutes of Health

Grant: 1R21DA057493-01A1

Using the Transdermal Patch for Buprenorphine Induction during Pregnancy: A Pilot Randomized Controlled Trial

National Institutes of Health

Grant: 5T32GM136554-03

The Clinical Translational Research Certificate of Added Qualification Program

National Institutes of Health

Grant: 5R01AI141501-02

Immune activating syncytiotrophoblast microvesicles and danger associated molecular patterns in preeclampsia risk

NIGMS NIH HHS

Grant: DP2 GM137418

NIGMS NIH HHS

Grant: T32 GM136554

NIDA NIH HHS

Grant: R21 DA057493

NIGMS NIH HHS

Grant: P20 GM121298

NICHD NIH HHS

Grant: R01 HD113199

NICHD NIH HHS

Grant: R01 HD091218

NIAID NIH HHS

Grant: R01 AI141501

NICHD NIH HHS

Grant: R01 HD110408

greenLicense: cc-by-nc-nd

repositoryhttps://doi.org/10.1101/2024.09.25.614931

publisherhttps://syndication.highwire.org/content/doi/10.1101/2024.09.25.614931

repositoryhttps://pubmed.ncbi.nlm.nih.gov/39386577

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/11463380

Fields of Study

COVID-19 Impact on ReproductionNeonatal Respiratory Health ResearchExtracellular vesicles in disease

Keywords

Cell biologySyncytiotrophoblastTrophoblastAutophagyBiologyPDZ domainSecretionExtracellularExtracellular vesicleMicrovesiclesPlacentaBiochemistrymicroRNAGeneFetusGeneticsApoptosisArticleCD63COVID-19intrinsically disordered proteintight junctions

Sustainable Development Goals

SDG 0: Good health and well-being