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Conformational plasticity across phylogenetic clusters of RND multidrug efflux pumps and its impact on substrate specificity

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.11.22.624703Source: DataRank Database

Conformational plasticity across phylogenetic clusters of RND multidrug efflux pumps and its impact on substrate specificity is a research paper published in bioRxiv (Cold Spring Harbor Laboratory) (2024). On theSindex it has a DataRank of 0. It has been cited 3 times.

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Open Access3 citations

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (2 grants)OA: greenTopics (27)IDs (PubMed, OpenAlex)

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Authors (15)

Thomas Eicher,Clara Börnsen ORCID,Hui Zeng ORCID,Mohd Athar ORCID,Ui Okada ORCID

Live enrichment

PubMed:39605333 OpenAlex:https://openalex.org/W4404652439

National Institutes of Health

Grant: 5R01AI136799-04

Optimization of efflux avoidance and inhibition for antibiotic development

NIAID NIH HHS

Grant: R01 AI136799

greenLicense: cc-by-nd

repositoryhttps://doi.org/10.1101/2024.11.22.624703

publisherhttps://syndication.highwire.org/content/doi/10.1101/2024.11.22.624703

repositoryhttps://pubmed.ncbi.nlm.nih.gov/39605333

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/11601597

Fields of Study

RNA and protein synthesis mechanismsViral Infections and Immunology ResearchTuberculosis Research and Epidemiology0301 basic medicine03 medical and health sciences

Keywords

EffluxSubstrate (aquarium)BiologyPhylogenetic treeChemistryEcologyGeneticsGeneATP-Binding Cassette, Sub-Family C ProteinsModels, MolecularBinding SitesProtein ConformationEscherichia coli ProteinsCryoelectron MicroscopyMembrane Transport ProteinsArticleSubstrate SpecificityAnti-Bacterial AgentsBacterial ProteinsDrug Resistance, Multiple, BacterialEscherichia coliPhylogeny