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12-Lipoxygenase inhibition improves glucose homeostasis and obesity-associated inflammation in human gene replacement mice

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.01.10.632274Source: DataRank Database

12-Lipoxygenase inhibition improves glucose homeostasis and obesity-associated inflammation in human gene replacement mice is a research paper published in bioRxiv (Cold Spring Harbor Laboratory) (2025). On theSindex it has a DataRank of 0.

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Enrichment:Funding (8 grants)OA: greenTopics (21)IDs (PubMed, OpenAlex)SDGs (1)

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Authors (13)

Titli Nargis ORCID,Kayla Figatner,Jiayi Wang ORCID,Sarida Pratuangtham ORCID,Advaita Chakraborty

Live enrichment

PubMed:39868153 OpenAlex:https://openalex.org/W4406311133

National Institutes of Health

Grant: 5T32DK007011-23

INTEGRATED CLINICAL AND BASIC ENDOCRINOLOGY RESEARCH

National Institutes of Health

Grant: 1R41DK122917-01A1

Novel therapeutic for treatment of type 1 diabetes

National Institutes of Health

Grant: 2P30DK020595-36

Core B: Molecular Biol. Genetics Core

National Institutes of Health

Grant: 1R03TR003381-01

The 12-HETE receptor Gpr31 in the -cell pathogenesis of type 1 diabetes

NIDDK NIH HHS

Grant: P30 DK020595

NCATS NIH HHS

Grant: R03 TR003381

NIDDK NIH HHS

Grant: R41 DK122917

NIDDK NIH HHS

Grant: T32 DK007011

greenLicense: cc-by-nc-nd

repositoryhttps://www.biorxiv.org/content/biorxiv/early/2025/01/13/2025.01.10.632274.full.pdf

publisherhttps://syndication.highwire.org/content/doi/10.1101/2025.01.10.632274

repositoryhttps://doi.org/10.1101/2025.01.10.632274

repositoryhttps://pubmed.ncbi.nlm.nih.gov/39868153

Fields of Study

Adipose Tissue and MetabolismAdipokines, Inflammation, and Metabolic DiseasesPeroxisome Proliferator-Activated Receptors

Keywords

InflammationGlucose homeostasisHomeostasisObesityLipoxygenaseArachidonate 5-lipoxygenaseEndocrinologyInternal medicineMedicineChemistryBiochemistryInsulin resistanceEnzymeArticlemacrophagemouse modelpancreatic islettype 2 diabetes

Sustainable Development Goals

SDG 0: Good health and well-being