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Binding Kinetics, Bias, Receptor Internalization and Effects on Insulin Secretion in vitro and in vivo of a Novel GLP-1R/GIPR Dual Agonist, HISHS-2001

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.01.13.632834Source: DataRank Database

Binding Kinetics, Bias, Receptor Internalization and Effects on Insulin Secretion in vitro and in vivo of a Novel GLP-1R/GIPR Dual Agonist, HISHS-2001 is a research paper published in bioRxiv (Cold Spring Harbor Laboratory) (2025). On theSindex it has a DataRank of 0. It has been cited 2 times.

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Open Access2 citations

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Enrichment:Funding (3 grants)OA: greenTopics (22)IDs (PubMed, OpenAlex)Annotations (1)

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Authors (12)

Ben Jones ORCID,Gaëlle Carrat ORCID,Zenouska Ramchunder ORCID,Piero Marchetti ORCID,Isabelle Leclerc ORCID

Live enrichment

PubMed:39868265 OpenAlex:https://openalex.org/W4406495237

Wellcome Trust

Grant: WT212625/Z/18/Z

Diabetes UK

Grant: 16/0005485

Wellcome Trust

Grant: 301619/Z/23/Z

greenLicense: cc-by-nc-nd

repositoryhttps://www.biorxiv.org/content/biorxiv/early/2025/01/17/2025.01.13.632834.full.pdf

repositoryhttps://doi.org/10.1101/2025.01.13.632834

repositoryhttps://pubmed.ncbi.nlm.nih.gov/39868265

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/11760779

Fields of Study

Diabetes Treatment and ManagementPancreatic function and diabetesReceptor Mechanisms and Signaling

Keywords

InternalizationIn vivoAgonistIn vitroKineticsChemistryReceptorEndocrinologyInternal medicineSecretionInsulinDual (grammatical number)Cell biologyBiologyBiochemistryMedicinePhysicsPhilosophyGenetics

Binding Kinetics, Bias, Receptor Internalization and Effects on Insulin Secretion in vitro and in vivo of a Novel GLP-1R/GIPR Dual Agonist, HISHS-2001

FAIR Checklist

Authors (12)

Funding (3 grants)

Open Access

Topics

Annotations (Europe PMC)