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Allosteric Modulation of Pathological Ataxin-3 Aggregation: A Path to Spinocerebellar Ataxia Type-3 Therapies

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.01.22.633970Source: DataRank Database

Allosteric Modulation of Pathological Ataxin-3 Aggregation: A Path to Spinocerebellar Ataxia Type-3 Therapies is a research paper published in bioRxiv (Cold Spring Harbor Laboratory) (2025). On theSindex it has a DataRank of 0.

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Enrichment:Funding (4 grants)OA: greenTopics (18)IDs (PubMed)

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Authors (27)

Sara Duarte‐Silva ORCID,Pedro M. Martins ORCID,Beatriz Rodrigues ORCID,Débora Serrenho ORCID,Daniela Vilasboas‐Campos ORCID

Live enrichment

PubMed:39896516

National Institutes of Health

Grant: 1S10OD018504-01

High-Resolution Ion Mobility Mass Spectrometer

European Commission

Grant: 952334

Excellence Hub on Phase Transitions in Aging and Age-Related Disorders

National Institutes of Health

Grant: 3R01AG050721-02S1

Misfolded protein-clearance enhancers for Alzheimer's therapy

National Institutes of Health

Grant: 5R35GM145286-02

Advancing Mass Spectrometry Analyses of Proteins, Assemblies, and Proteoforms

greenLicense: cc-by-nc-nd

repositoryhttps://www.biorxiv.org/content/biorxiv/early/2025/01/24/2025.01.22.633970.full.pdf

publisherhttps://syndication.highwire.org/content/doi/10.1101/2025.01.22.633970

repositoryhttps://pmc.ncbi.nlm.nih.gov/articles/PMC11785186/pdf/nihpp-2025.01.22.633970v1.pdf

https://doi.org/10.1101/2025.01.22.633970

https://pubmed.ncbi.nlm.nih.gov/39896516

Fields of Study

03 medical and health sciences0302 clinical medicine

Keywords

AmyloidMolecular therapies31 Biological Sciences (for-2020)Neurological (hrcs-hc)Protein dynamicsPre-clinical modelsArticle3101 Biochemistry and Cell Biology (for-2020)Rare Diseases (rcdc)Aging (rcdc)Brain Disorders (rcdc)5.1 Pharmaceuticals (hrcs-rac)Orphan Drug (rcdc)PolyglutamineNeurosciences (rcdc)Neurodegenerative (rcdc)