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Single-nucleus analysis reveals oxidative stress in Down syndrome basal forebrain neurons at birth

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.02.05.636750Source: DataRank Database

Single-nucleus analysis reveals oxidative stress in Down syndrome basal forebrain neurons at birth is a research paper published in bioRxiv (Cold Spring Harbor Laboratory) (2025). On theSindex it has a DataRank of 0. It has been cited 1 time.

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (8 grants)OA: greenTopics (23)IDs (PubMed, OpenAlex)

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Open Access

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Authors (12)

Kalpana Hanthanan Arachchilage ORCID,Sara Knaack ORCID,Shawn MacGregor,Masoumeh Hosseini ORCID,Ryan D. Risgaard ORCID

Live enrichment

PubMed:39975363 OpenAlex:https://openalex.org/W4407239681

NIA NIH HHS

Grant: F99 AG086925

NIA NIH HHS

Grant: R36 AG072108

NICHD NIH HHS

Grant: P50 HD105353

NIMH NIH HHS

Grant: F30 MH140382

NIGMS NIH HHS

Grant: T32 GM140935

NICHD NIH HHS

Grant: R01 HD106197

NICHD NIH HHS

Grant: P30 HD003352

NICHD NIH HHS

Grant: R25 HD114950

greenLicense: cc-by-nd

repositoryhttps://doi.org/10.1101/2025.02.05.636750

publisherhttps://syndication.highwire.org/content/doi/10.1101/2025.02.05.636750

repositoryhttps://pubmed.ncbi.nlm.nih.gov/39975363

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/11839037

Fields of Study

Down syndrome and intellectual disability researchAutism Spectrum Disorder ResearchGenetic Neurodegenerative Diseases

Keywords

NeurodegenerationBasal forebrainBiologyForebrainCholinergic neuronOxidative phosphorylationInternal medicineNeuroscienceCholinergicCell biologyBiochemistryCentral nervous systemDiseaseMedicineBasal Forebrain Cholinergic Neurons (BFCNs)Down syndromeGlycolysisOxidative Phosphorylation (OXPHOS)Reactive Oxygen Species (ROS)snMultiomic Analysis